Book ChapterDOI
The Blood Brain Barrier
Hugh Davson
- pp 381-396
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TLDR
The concept of a barrier between blood and brain and the brain and spinal cord derives from the classical studies of Ehrlich and of Goldmann on vital staining but in the thirties and forties some doubt was cast on this concept.Abstract:
The concept of a barrier between blood, on the one hand, and the brain on the other derives from the classical studies of Ehrlich and of Goldmann on vital staining; it was noted that a large variety of acid dyes, of which trypan blue was one, would pass out of the blood into the tissues of the body making them voloured; the brain and spinal cord stood out in contrast to the rest of the tissues in that, with the exception of highly localized regions, such as the area postrema, they remained unstained. In the thirties and forties of this century some doubt was cast on this concept of a barrier between blood and brain; thus King in 1938 (1) argued that the essential phenomenon was one of failure to stain, and this could have been due to the absence of suitable connective tissue to take up the stain.read more
Citations
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Journal ArticleDOI
A new look at cerebrospinal fluid circulation
TL;DR: Challenging this concept are novel insights utilizing molecular and cellular biology as well as neuroimaging, which indicate that CSF physiology may be much more complex than previously believed.
Journal ArticleDOI
The blood-brain barrier and immune function and dysfunction.
TL;DR: Four aspects of BBB-neuroimmune interactions are considered: BBB disruption as mediated by LPS and cytokines, cytokine transport across theBBB, immune cell trafficking, and effects of lipopolysaccharide (LPS) on various functions of the BBB.
BookDOI
Implications of the Blood-Brain Barrier and Its Manipulation
TL;DR: A view of brain pathophysiology and therapy from the perspective of the blood-brain barrier is presented, showing how future brain treatments with regulatory peptides, immune mediators, and gene components will require selective methods to deliver these agents to specific brain regions.
References
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Journal ArticleDOI
Junctional complexes in various epithelia
TL;DR: The tight junction is impervious to concentrated protein solutions and appears to function as a diffusion barrier or "seal," and the desmosome and probably also the zonula adhaerens may represent intercellular attachment devices.
Journal ArticleDOI
Fine structural localization of a blood-brain barrier to exogenous peroxidase
TL;DR: These findings localize, at a fine structural level, a "barrier" to the passage of peroxidase at the endothelium of vessels in the cerebral cortex in mice, particularly with reference to a recent study in which similar techniques were applied to capillaries in heart and skeletal muscle.
Journal ArticleDOI
Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
Journal ArticleDOI
The ultrastructural basis of capillary permeability studied with peroxidase as a tracer
TL;DR: It is concluded that the endothelial cell junctions are most likely to be the morphological equivalent of the small pore system proposed by physiologists for the passage of small, lipid-insoluble molecules across the endothelium.