Journal ArticleDOI
The cardioactivity of digitoxin metabolites
Heinz Lüllmann,Thies Peters +1 more
TLDR
Using isolated atria, the positive inotropic action of digitoxin and digoxin was compared quantitatively with the cardiac action of metabolites found in guinea pigs and the bis- and monodigitoxoside of digitoxigenin showed the strongest inotropic effect with respect to the affinity and the maximum response.About:
This article is published in European Journal of Pharmacology.The article was published on 1971-04-01. It has received 28 citations till now. The article focuses on the topics: Digitoxigenin & Digitoxin.read more
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Book ChapterDOI
Digitalis: its mode of action, receptor, and structure-activity relationships
Journal ArticleDOI
The significance of a fast exchanging superficial calcium fraction for the regulation of contractile force in heart muscle
TL;DR: It is suggested that the fast exchanging Ca compartment is superficially located and is responsible for rapid changes in contractile force and may provide a Ca concentration of about 1.5 × 10−5 m in the intracellular aqueous space, which is generally believed to be sufficient for the activation of contraction.
Journal ArticleDOI
Correlation between inhibition of (Na+, K+)-membrane-ATPase and positive inotropic activity of cardenolides in isolated papillary muscles of guinea pig.
H. Flasch,N. Heinz +1 more
TL;DR: The concentrations necessary for inhibition of (Na+, K+)-membrane-ATPase of the guinea pig heart and the concentrations required to achieve a defined positive inotropic effect in Guinea pig papillary muscle showed a log/log correlation coefficient of 0.97, support Repke's hypothesis on the digitalis receptor.
Journal ArticleDOI
Cardiac glycosides: prerequisites for the development of new cardiotonic compounds.
Th. W. Güntert,Horst H. A. Linde +1 more
TL;DR: Two prerequisites in a successful search for cardiac glycosides are the separability of the inotropicallyactive from the toxically-active component and knowledge of their structure-activity relationships and/or indispensible structural features.
Journal ArticleDOI
Influence of Gastric Acidity on the Bioavailability of Digoxin
TL;DR: The data suggest that gastric acidity causes the breakdown of digoxin to products that cross-react in the assay (EIA) that is commonly used clinically, and Omeprazole, and presumably other gastric-acid inhibitors, may increase the bioavailability of unchanged digoxin.