Book ChapterDOI
The Dynamic Parameter
Melvin Schindler,Paramjit K. Gharyal,Lian-Wei Jiang +2 more
- pp 261-281
Reads0
Chats0
TLDR
Correspondent response to the environment may be viewed as the result of a linked web of dissipative molecular gradients across biological membranes that initiate and transmit environmental information and cellular status.Abstract:
The viability of organisms is dependent on the controlled flow of information and metabolic/synthetic precursors between cellular compartments. Such processes are elaborated upon as a hierarchy of interdependence established between cells and tissues. Through the ebb and flow of signaling and metabolic molecules, dynamic linkages may be maintained between cells for the coordination, synchronization, and initiation of cellular cycles (Fig. 1). In this manner, organismal response to the environment may be viewed as the result of a linked web of dissipative molecular gradients across biological membranes that initiate and transmit environmental information and cellular status. Integration of these gradients over large numbers of cells and tissues collectively leads to spatial and/or temporal responses. The biological structures that serve as controllable elements for transmembrane molecular flow are generally classified as channels or pores that serve either as passive transport routes for low-molecular-weight molecules (Loewenstein, 1979; Nikaido and Nakae, 1979; Gunning and Overall, 1983) or as ion pumps or transporters requiring some type of coupled gradient dissipation or energy
Open image in new window
Figure 1
Dynamic linkages between organelles and cells. Chemical gradients are utilized to transmit information between the cell and the environment. The pathways involved in this transmission system are: lateral mobility of membrane receptors (1); transplasma membrane transport through channels, pores, and transporters (2); homotypic intercellular communication through gap junctions or plasmodesmata (3); nucleocytoplasmic transport (4); translysosomal or vacuolar membrane transport of H+ and ions (5); Golgi-mediated processing, secretion, and recycling (6); Golgi transport of newly synthesized proteins (cis-medial-trans) (7); heterotypic intercellular communication (8). R, N, and G represent membrane receptors, the nucleus, and Golgi, respectively.
source for molecular transposition (Mitchell, 1979; Noma, 1983; Reuter et al., 1983). In most instances, the control of these channels is mediated by ligand-specific receptors that couple to the channels under activating conditions, initiating a cascade of enzymatic changes resulting in a modification of channel transport properties (Koshland, 1981; Bean et al., 1983; Hondeghem and Katzung, 1984). In other cases, transport channels and receptors are intimately linked, forming a common structure, as in the case of the nicotinic acid receptor/channel (Conti-Tronconi and Raftery, 1982).read more
Citations
More filters
Journal Article
Diffusion of injected macromolecules within the cytoplasm of living cells
TL;DR: It is suggested that cytoplasmic diffusion rates are reduced relative to rates in aqueous media as a result of increased aQueous phase viscosity or the impedence provided by structural elements.
References
More filters
Journal ArticleDOI
ATP-regulated K + channels in cardiac muscle
TL;DR: Application of the patch-clamp technique to CN-treated mammalian heart cells reveals specific K+ channels which are depressed by intracellular ATP (ATPi) at levels greater than 1 mM, which seems to be important for regulation of cellular energy metabolism in the control of membrane excitability.
Journal ArticleDOI
Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins.
TL;DR: The most prominent structural feature of both lamins is an α-helical region of repeating heptads of amino acids that shows striking homology with the entire family of cytoplasmic intermediate filament proteins, suggesting that the nuclear envelope is made up of a network of coiled-coil polymers.
Journal ArticleDOI
Nuclear envelope permeability.
TL;DR: The permeability of the amphibian oocyte nuclear envelope in situ has been determined for three tritiated dextrans and the envelope is a sieve restricting molecular movement between the cytoplasm and nucleus.