Journal ArticleDOI
The effect of crystal morphology and mill type on milling induced crystal disorder
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TLDR
It is suggested that beta-succinic acid crystals with plate like morphology are more prone to crystallinity loss on milling compared to the needle like morphology, as the mill type has also been shown to influence the final crystallinity.About:
This article is published in European Journal of Pharmaceutical Sciences.The article was published on 2006-01-01. It has received 104 citations till now. The article focuses on the topics: Jet mill & Ball mill.read more
Citations
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Journal ArticleDOI
Influence of size scale and morphology on antibacterial properties of ZnO powders hydrothemally synthesized using different surface stabilizing agents.
TL;DR: The highest microbial cell reduction rate was recorded for the synthesized ZnO powder consisting of nanospherical particles, and in all of the examined samples, ZnNO particles demonstrated a significant bacteriostatic activity.
Journal ArticleDOI
Engineering of pharmaceutical materials: An industrial perspective
TL;DR: This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development.
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The Effects of Milling on the Surface Properties of Form I Paracetamol Crystals
TL;DR: The effects of milling and particle size on surface energies of form I paracetamol crystals are reported, exposing facets of different surface chemistry to that of the native external facets.
Journal ArticleDOI
Methods of amorphization and investigation of the amorphous state
TL;DR: How amorphous state of pharmaceuticals differ depending on the method of preparation and how these differences can be screened by a variety of spectroscopic methods and calorimetry methods are described.
Journal ArticleDOI
Effect of Milling on Particle Shape and Surface Energy Heterogeneity of Needle-Shaped Crystals
Raimundo Ho,Majid Naderi,Jerry Y. Y. Heng,Daryl R. Williams,Frank Thielmann,Peter Bouza,Adam R. Keith,Greg Thiele,Daniel J. Burnett +8 more
TL;DR: It is demonstrated that particle shape is an important factor affecting the fracture mechanism in milling, and crystal size, and more importantly, crystal shape and facet-specific mechanical properties, can dictate the fracture/cleavage behavior of organic crystalline materials.
References
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Book
Encyclopedia of Pharmaceutical Technology
TL;DR: Compounding, Contemporary, andProcess Chemistry in the Pharmaceutical Industry: Characterization and Function, Volume 19.
Journal ArticleDOI
Thermal analysis and calorimetric methods in the characterisation of polymorphs and solvates
TL;DR: In this paper, the authors present a review of the use of thermal analysis for the analysis of polymorphism and pseudo-polymorphism in drug substances and excipients, including solvates and impurities.
Journal ArticleDOI
(D) Routes of delivery: Case studies
John S. Patton,Robert M. Platz +1 more
TL;DR: A dense network of endocytic vesicles in the type-1 alveolar epithelial cells offers a possible mechanism to explain how the airsacs remain nearly free of fluid and how macromolecules are subsequently absorbed.
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