Journal ArticleDOI
The effect of potassium dichromate on convoluted tubules of the kidney of adult male albino rats and the possible protective role of ginseng: a histological and immunohistochemical study
TLDR
Ginseng has a protective effect against potassium dichromate-induced nephrotoxicity as it has antioxidant, anti-inflammatory, and antiapoptotic activities.Abstract:
Background Chromium is a heavy metal used in painting, dyes, and leather tanning industries. Potassium dichromate Cr6+ has demonstrated ability to induce nephrotoxicity associated with oxidative stress in humans and animals. Ginseng is one of the most popular herbal remedies, with a wide range of beneficial therapeutic effects. Objective The aim of the study was to evaluate the effect of potassium dichromate on the convoluted tubules of adult male albino rats and the possible protective role of ginseng. Materials and methods Forty adult male rats were divided equally into four groups (10 rats for each): Group I was the control group. In group II (the ginseng group), rats received a daily oral dose of ginseng at 100 mg/kg body weight/day by means of a gastric tube for 3 weeks. In group III (the potassium dichromate group), rats received a single subcutaneous injection of potassium dichromate at 15 mg/kg body weight. In group IV (the potassium dichromate and ginseng group), rats received potassium dichromate and ginseng for 3 weeks. Kidney specimens were prepared for light microscopic examination {stained with (H&E), Masson’s trichrome, immunohistochemical detection of caspase-3}. Semithin and ultrathin sections were prepared for electron microscopic examination. Results Group III showed degeneration and necrosis of cells of the renal tubules (proximal and distal) with tubular dilatation, an increase in collagen fibers around degenerated convoluted tubules, and cell apoptosis (highly expressed caspase-3). Electron microscopic results showed marked disrupted brush border of proximal convoluted tubules and disturbance of the basal infoldings of distal convoluted tubules. The cytoplasm had mitochondria that were irregular in shape and variable in size and large electron-dense particles. The smooth endoplasmic reticulum membrane revealed whorly appearance around the degenerated organelles. Group IV showed improvement in the light and electron microscopic changes described before. Conclusion Ginseng has a protective effect against potassium dichromate-induced nephrotoxicity as it has antioxidant, anti-inflammatory, and antiapoptotic activities. We advice the workers who deal with chromium to take enough doses of ginseng to protect themselves from its side effects.read more
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Principles and Techniques of Electron Microscopy: Biological Applications
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Mechanism of chromium-induced toxicity in lungs, liver, and kidney and their ameliorative agents.
Rituraj Chakraborty,Kaviyarasi Renu,Mohamed Ahmed Eladl,Mohamed El-Sherbiny,Dalia Mahmoud Abdelmonem Elsherbini,Arshiya Mirza,Balachandar Vellingiri,Mahalaxmi Iyer,Abhijit Dey,Abilash Valsala Gopalakrishnan +9 more
TL;DR: In this article , heavy metal Chromium (Cr) exposure is associated with liver, lung, kidney damage, widespread dermatitis, GI tract damage, human lung cancer, cardiomyopathies, and cardiovascular disease.
Reno-Protective Effects of Egyptian Herbal Formula during Experimental Diabetes
TL;DR: The Reno-protective effects of an Egyptian Herbal mixture formulation (HMF) consisting of (Panax ginseng, Momordica charantia and Gymnema sylvestre) on diet intake, bodyweight, water consumption, urine output, urine sugar, urine protein and renal oxidative stress marker malondialdehyde in rats are estimated.
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Histological study on the possible protective effect of curcumin on potassium dichromate induced hypothyroidism in adult male albino rats
TL;DR: Curcumin had protective effect against hypothyroidism and thyroid tissue damage induced by potassium dichromate in albino rats.
Journal ArticleDOI
Structural Changes Induced by Potassium Dichromate in Renal Cortex of Adult Male Albino Rats and the Possible Protective Role of Selenium
TL;DR: It is suggested that administration of selenium mod-erately improves the deleterious histological and biochemical changes induced by Cr on renal cortex.
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Principles and Techniques of Electron Microscopy: Biological Applications
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Ascorbic acid and alpha-tocopherol protect anticancer drug cisplatin induced nephrotoxicity in mice: a comparative study.
TL;DR: Higher doses of vitamins are effective to protect oxidative renal damage and vitamin C is the better nephroprotective agent than vitamin E.
Journal ArticleDOI
Is Hexavalent Chromium Carcinogenic via Ingestion? A Weight-Of-Evidence Review
Deborah M. Proctor,Joanne M. Otani,Brent L. Finley,Dennis J. Paustenbach,Judith A. Bland,Ned A. Speizer,Edward V. Sargent +6 more
TL;DR: The weight of scientific evidence supports that Cr(VI) is not carcinogenic in humans via the oral route of exposure at permissible drinking-water concentrations.
Journal ArticleDOI
Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis.
Dan Zhu,Lei Wu,Chun-Rong Li,Xiao-Wei Wang,Yong-Jie Ma,Zhiyin Zhong,Haibao Zhao,Jian Cui,Si-Fan Xun,Xiu-Lan Huang,Zhe Zhou,Sheng-Qi Wang +11 more
TL;DR: The myocardial protection of ginsenoside Rg1 during H/R is partially due to its antioxidative effect and intracellular calcium homeostasis.
Journal ArticleDOI
Effect of fermented Panax ginseng extract (GINST) on oxidative stress and antioxidant activities in major organs of aged rats.
Thiyagarajan Ramesh,Sung-Won Kim,Jong-Hwan Sung,Seock-Yeon Hwang,Sang-Hyon Sohn,Sung-Kwang Yoo,Si-Kwan Kim +6 more
TL;DR: It is suggested that treatment of GINST can improve the antioxidant status during aging, thereby minimizing the oxidative stress and occurrence of age-related disorders associated with free radicals.
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