Journal ArticleDOI
The electron microscopic localization of methionine-enkephalin within the superficial layers (I and II) of the spinal cord.
S.P. Hunt,J.S. Kelly,P. C. Emson +2 more
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The investigated synaptic relationships of methionine-enkephalin containing axon terminals within layers I and II of the rat spinal cord were unable to find a morphological correlate of the reported effects of opiates on sensory axons and terminals.About:
This article is published in Neuroscience.The article was published on 1980-11-01. It has received 231 citations till now. The article focuses on the topics: Synaptic vesicle & Axon.read more
Citations
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Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry.
Journal ArticleDOI
Spinal and Trigeminal Mechanisms of Nociception
Ronald Dubner,Gary J. Bennett +1 more
TL;DR: The development of new experimental approaches has led to recent advances in knowledge of spinal and trigeminal nociceptive mechanisms, justifying another review of the rapidly proliferating literature in this field.
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Mismatches between neurotransmitter and receptor localizations in brain: observations and implications.
Journal ArticleDOI
Peptidergic transmission in sympathetic ganglia of the frog.
Lily Yeh Jan,Yuh Nung Jan +1 more
TL;DR: Physiological and anatomical evidence is presented which indicates that the peptidergic transmitter for the late slow e.p.s.p., probably mediated by a peptide resembling luteinizing hormone‐releasing hormone, can diffuse for many micrometres before acting on ganglion cells.
References
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Periodate-lysine-paraformaldehyde fixative a new fixative for immunoelectron microscopy
Ian W. Mclean,Paul K. Nakane +1 more
TL;DR: Using this fixative and the peroxidase-labeled antibody technique, basement membrane antigen was localized within the cisternae of endoplasmic reticulum of parietal yolk sac cells and in extracellular basement membranes with adequate tissue preservation, a task which has not been successfully accomplished by conventional fixatives.
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Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
T. M. Jessell,L. L. Iversen +1 more
TL;DR: It is reported here that opiate analgesics are able to suppress the stimulus-evoked release of SP, which may represent a mechanism for the direct spinal analgesic actions of opiates.
Journal ArticleDOI
Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P
TL;DR: The present immunohistochemical-anatomical findings support the hypothesis that stimulation-produced analgesia is related to activation of spinal and spinal trigeminal enkephalin interneurons forming axo-axonic synapses with (substance P?) pain afferents in the superficial laminae of the dorsal horn and the spinal trigEMinal nucleus.
Related Papers (5)
Opiate analgesics inhibit substance P release from rat trigeminal nucleus.
T. M. Jessell,L. L. Iversen +1 more