The endocrine polypeptide cells of the human stomach, duodenum, and jejunum.
TLDR
Although there was wide variation in the distribution of the various cells, from one case to another, striking differences were nevertheless observable, with respect to the G cell, between antra from carcinoma and from ulcer cases.Abstract:
Thirty specimens of stomach, duodenum, and jejunum, removed at operation, were examined by optical microscopical, cytochemical, and electron microscopical techniques. The overall distribution of four types of endocrine polypeptide cell in the stomach, and three in the intestine, was determined. The seven cell types are described by names and letters belonging to a scheme for nomenclature agreed upon at the 1969 Wiesbaden conference on gastrointestinal hormones. The gastrin-secreting G cell was the only cell for which firm identification with a known hormone was possible. Although there was wide variation in the distribution of the various cells, from one case to another, striking differences were nevertheless observable, with respect to the G cell, between antra from carcinoma and from ulcer cases.read more
Citations
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Ghrelin, CCK, GLP-1, and PYY(3-36): Secretory Controls and Physiological Roles in Eating and Glycemia in Health, Obesity, and After RYGB.
Robert E. Steinert,Christine Feinle-Bisset,Lori Asarian,Michael Horowitz,Christoph Beglinger,Nori Geary +5 more
TL;DR: Gastric emptying, the detection of specific digestive products by small intestinal enteroendocrine cells, and synergistic interactions among different GI loci all contribute to the secretion of ghrelin, CCK, GLP-1, and PYY(3-36).
Journal ArticleDOI
The histological diagnosis of chronic gastritis in fibreoptic gastroscope biopsy specimens
TL;DR: A classification of chronic gastritis is proposed that includes the type of mucosa, the type and stage of activity of the gastritis, and the presence and type of metaplasia and is sufficiently flexible to allow within it quantitative assessment of individual histological features.
Journal ArticleDOI
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine III. Entero‐endocrine cells
Hazel Cheng,C. P. Leblond +1 more
TL;DR: The origin, differentiation and renewal of entero-endocrine cells was examined in the duodenum, jejunum and ileum of the mouse using light and electron microscopic radioautography after a single injection or continuous infusion of 3H-thymidine.
Journal ArticleDOI
Renewal of the epithelium in the descending colon of the mouse. I. Presence of three cell populations: vacuolated-columnar, mucous and argentaffin.
W. W. L. Chang,C. P. Leblond +1 more
TL;DR: The epithelium of the descending colon of the mouse was examined in the mouse using one-micron thick Epon embedded sections of formaldehyde-fixed tissues stained with the periodic acid-Schiff and iron-hematoxylin techniques, and radioautographed at various time intervals after a single injection of tritium labeled thymidine.
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A gastrin releasing peptide from the porcine nonantral gastric tissue.
TL;DR: Evidence for the existence in extracts from porcine non-antral gastric tissue of a peptide capable of causing substantial rises of plasma immunoreactive gastrin levels in a dose dependent manner and of stimulation of gastric acid and pepsin secretion is presented.
References
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Origin and distribution of the hyperglycemic-glycogenolytic factor of the pancreas.
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Characterization of the responses of circulating glucagon-like immunoreactivity to intraduodenal and intravenous administration of glucose.
TL;DR: It is concluded that hyperglycemia does not stimulate and probably suppresses the secretion of pancreatic glucagon, and that during intestinal absorption of glucose, a rise in glucagon-like immunoreactivity occurs, favoring the gut as the likely source of the rise.
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THE ENDOCRINE CELLS IN THE EPITHELIUM OF THE GASTROINTESTINAL MUCOSA OF THE RAT : An Electron Microscope Study
TL;DR: The authors of this study examine the question of whether the so-called enterochromaffin or argentaffin cells of the gastrointestinal tract should be considered as a single cell type, and their appearance corresponds to that of pancreatic D cells.
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Lead-haematoxylin as a stain for endocrine cells. Significance of staining and comparison with other selective methods.
TL;DR: A modification of MacConaill's lead-haematoxylin has been found to stain several endocrine cells producing polypeptides and monoamines, particularly A and D cells of the pancreatic islet, thyroid C cells, gastro-intestinal enterochromaffin cells, gastric G and X cells, pituitary ACTH and MSH cells, adrenal medullary cells, and chemoreceptive cells ofthe carotid body.