The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
Reads0
Chats0
About:
This article is published in Proceedings of the National Academy of Sciences of the United States of America.The article was published on 1968-10-01 and is currently open access. It has received 1713 citations till now. The article focuses on the topics: Heme oxygenase & Heme.read more
Citations
More filters
Journal ArticleDOI
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
TL;DR: This review highlights the current information on molecular and biochemical properties of HO-1 and HO-2 and addresses the possible mechanisms for mutual regulatory interactions between the CO- and NO-generating systems.
Journal ArticleDOI
Heme-Containing Oxygenases
Journal ArticleDOI
Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
TL;DR: The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
Journal ArticleDOI
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Leo E. Otterbein,Leo E. Otterbein,Fritz H. Bach,Jawed Alam,Miguel P. Soares,Hong-Tao Lu,Mark Allen Wysk,Roger J. Davis,Richard A. Flavell,Augustine M.K. Choi,Augustine M.K. Choi +10 more
TL;DR: It is demonstrated here that carbon monoxide, a by-product of heme catabolism by heme oxygenase, mediates potent anti-inflammatory effects and may have an important protective function in inflammatory disease states and thus has potential therapeutic uses.
Journal ArticleDOI
Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.
TL;DR: In this review recent findings on heme oxygenase are highlighted and it is shown that the enzyme activity is inhibited in vivo for extended periods subsequent to binding of Zn- and Sn- protoporphyrins.
References
More filters
Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal Article
Pharmacological implications of microsomal enzyme induction
TL;DR: It is of considerable interest that certain inducers of liver microsomal enzymes have recently been used therapeutically for the treatment of hyperbilirubinemia in jaundiced children and for thetreatment of Cushing's syndrome.
Journal ArticleDOI
Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems
TL;DR: The agreement between photochemical action spectrum and spectrophotometric difference spectrum supports the conclusion that the CO-binding pigment is the terminal oxidase of mixed function oxidase systems of mammals.