Journal ArticleDOI
The glutathione S-transferases as a possible detoxification system of rat intestinal epithelium.
TLDR
The data arc consistent with a detoxification role for the glutathione S-transferases in intestine is consistent with that of liver.About:
This article is published in Biochemical Pharmacology.The article was published on 1977-12-15. It has received 78 citations till now. The article focuses on the topics: Glutathione & Intestinal epithelium.read more
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Book ChapterDOI
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.
TL;DR: The knowledge of the way in which mutagens and carcinogens are metabolized is essential to a better understanding of their mode of action and of the processes for their detoxication.
Journal ArticleDOI
Modeling of intestinal drug absorption: roles of transporters and metabolic enzymes (for the gillette review series)
TL;DR: The absorption of drugs via the oral route is a subject of intense and continuous investigation in the pharmaceutical industry since good bioavailability implies that the drug is able to reach the systemic circulation by mouth.
Journal Article
Expression and Localization of Multidrug Resistant Protein mrp2 in Rat Small Intestine
TL;DR: It is concluded that conjugating enzymes are distributed similarly to mrp2 and may act coordinately to contribute to first-pass metabolism of drugs and other xenobiotics in the proximal small intestine.
Journal ArticleDOI
Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver.
TL;DR: The enzyme has a molecular weight of 47,500 and is composed of two subunits of the same apparent molecular weight as mentioned in this paper, and is active in catalyzing the reaction of glutathione as a nucleophile, with a variety of compounds bearing an electrophilic center.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
Intestinal epithelial cell surface membrane glycoprotein synthesis. I. An indicator of cellular differentiation.
TL;DR: The results suggest that the more differentiated upper villus cells incorporate more labeled sugar precursors into membrane glycoproteins than the less differentiated lower villus or crypt cells and that these membrane gly coproteins are associated with membrane-bound enzymes.
Journal ArticleDOI
Mechanism for the several activities of the glutathione S-transferases.
TL;DR: The catalyzed reactions of GSH with organic nitrate and thiocyanate esters and with a series of chloronitrobenzene substrates have been investigated and the results suggest that the many diverse reactions catalyzed by the glutathione transferases may be formulated as a nucleophilic attack of enzyme-bound GSH on the electrophilic center of the second substrate.