Book ChapterDOI
The Isoenzymes of Glutathione Transferase
About:
This article is published in Advances in Enzymology and Related Areas of Molecular Biology.The article was published on 2006-11-22. It has received 855 citations till now.read more
Citations
More filters
Journal ArticleDOI
The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
John D. Hayes,David J. Pulford +1 more
TL;DR: The biochemical functions of GST are described to show how individual isoenzymes contribute to resistance to carcinogens, antitumor drugs, environmental pollutants, and products of oxidative stress, and to allow identification of factors that may modulate resistance to specific noxious chemicals.
Journal ArticleDOI
The importance of glutathione in human disease.
TL;DR: An overview of the biological importance of GSH at the level of the cell and organism can be found in this article, where the authors provide a review of the most prevalent non-protein thiol in animal cells.
Journal ArticleDOI
Glutathione transferases--structure and catalytic activity.
Bengt Mannervik,U H Danielson +1 more
TL;DR: The glutathione transferases are recognized as important catalysts in the biotransformation of xenobiotics, including drugs as well as environmental pollutants, and numerous transferases from mammalian tissues, insects, and plants have been isolated and characterized.
Journal ArticleDOI
The molecular basis of insecticide resistance in mosquitoes.
TL;DR: This paper reviews what is currently known about insecticide resistance conferred by metabolic or target site changes in mosquitoes.
Journal ArticleDOI
Glutathione S-Transferase Polymorphisms and Their Biological Consequences
John D. Hayes,Richard C. Strange +1 more
TL;DR: Two supergene families encode proteins with glutathione S-transferase (GST) activity that detoxify a variety of electrophilic compounds, including oxidized lipid, DNA and catechol products generated by reactive oxygen species-induced damage to intracellular molecules.
References
More filters
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Book ChapterDOI
The role of glutathione and glutathione S-transferases in the metabolism of chemical carcinogens and other electrophilic agents.
TL;DR: The knowledge of the way in which mutagens and carcinogens are metabolized is essential to a better understanding of their mode of action and of the processes for their detoxication.
Journal ArticleDOI
Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides.
TL;DR: The cell sap from pig liver contains a protein which protects phosphatidylcholine liposomes and biomembranes from peroxidative degradation in the presence of glutathione, and this protein appears to be distinct from the selenoenzyme glutATHioneperoxidase and from any known glutathion S-transferase.
Journal ArticleDOI
The refined structure of the selenoenzyme glutathione peroxidase at 0.2-nm resolution.
TL;DR: A general picture of a minimal reaction mechanism, in good agreement with functional and structural data, is proposed and a reasonable model of glutathione binding is presented.