The Hippocampus, Memory, and Place Cells: Is It Spatial Memory or a Memory Space?
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In this paper, the authors thank Eric Kandel, Richard Morris, Peter Rapp, and Larry Squire for their thoughtful comments and criticisms on versions of this manuscript, which is supported by grants from NIMH and NIA.About:
This article is published in Neuron.The article was published on 1999-06-01 and is currently open access. It has received 1023 citations till now.read more
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An integrative theory of prefrontal cortex function
Earl K. Miller,Jonathan D. Cohen +1 more
TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
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The medial temporal lobe
TL;DR: This analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system is principally concerned with memory and operates with neocortex to establish and maintain long-term memory.
Journal ArticleDOI
The Human Hippocampus and Spatial and Episodic Memory
TL;DR: A review of neuropsychological, behavioral, and neuroimaging studies of human hippocampal involvement in spatial memory concentrates on three important concepts in this field: spatial frameworks, dimensionality, and orientation and self-motion.
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The prefrontal cortex and cognitive control.
TL;DR: Studies indicate that the prefrontal cortex is central in this process, providing an infrastructure for synthesizing a diverse range of information that lays the foundation for the complex forms of behaviour observed in primates.
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Path integration and the neural basis of the 'cognitive map'
Bruce L. McNaughton,Bruce L. McNaughton,Francesco P. Battaglia,Ole Jensen,Edvard I. Moser,May-Britt Moser +5 more
TL;DR: Theoretical studies suggest that the medial entorhinal cortex might perform some of the essential underlying computations by means of a unique, periodic synaptic matrix that could be self-organized in early development through a simple, symmetry-breaking operation.
References
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The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
TL;DR: The amnesic syndrome is presented as an extension of the theory to humans and the role of operators in the locale system is examined.
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Loss of recent memory after bilateral hippocampal lesions.
TL;DR: The results of these studies point to the importance of the hippocampal complex for normal memory function in patients who had undergone similar, but less radical, bilateral medial temporallobe resections, and as a warning to others of the risk to memory involved in bilateral surgical lesions of the hippocampusal region.
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Cognitive maps in rats and men
TL;DR: Most of the rat investigations, which I shall report, were carried out in the Berkeley laboratory, and a few, though a very few, were even carried out by me myself.
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The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
TL;DR: Preliminary observations on the behaviour of hippocampusal units in the freely moving rat provide support for this theory of hippocampal function.
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Why there are complementary learning systems in the hippocampus and neocortex: insights from the successes and failures of connectionist models of learning and memory.
TL;DR: The account presented here suggests that memories are first stored via synaptic changes in the hippocampal system, that these changes support reinstatement of recent memories in the neocortex, that neocortical synapses change a little on each reinstatement, and that remote memory is based on accumulated neocorticals changes.