Journal ArticleDOI
Path integration and the neural basis of the 'cognitive map'
Bruce L. McNaughton,Bruce L. McNaughton,Francesco P. Battaglia,Ole Jensen,Edvard I. Moser,May-Britt Moser +5 more
TLDR
Theoretical studies suggest that the medial entorhinal cortex might perform some of the essential underlying computations by means of a unique, periodic synaptic matrix that could be self-organized in early development through a simple, symmetry-breaking operation.Abstract:
The hippocampal formation can encode relative spatial location, without reference to external cues, by the integration of linear and angular self-motion (path integration). Theoretical studies, in conjunction with recent empirical discoveries, suggest that the medial entorhinal cortex (MEC) might perform some of the essential underlying computations by means of a unique, periodic synaptic matrix that could be self-organized in early development through a simple, symmetry-breaking operation. The scale at which space is represented increases systematically along the dorsoventral axis in both the hippocampus and the MEC, apparently because of systematic variation in the gain of a movement-speed signal. Convergence of spatially periodic input at multiple scales, from so-called grid cells in the entorhinal cortex, might result in non-periodic spatial firing patterns (place fields) in the hippocampus.read more
Citations
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Journal ArticleDOI
Place Cells, Grid Cells, and the Brain's Spatial Representation System
TL;DR: How place cells and grid cells may form the basis for quantitative spatiotemporal representation of places, routes, and associated experiences during behavior and in memory is reviewed.
Journal ArticleDOI
Memory, navigation and theta rhythm in the hippocampal-entorhinal system
György Buzsáki,Edvard I. Moser +1 more
TL;DR: It is proposed that mechanisms of memory and planning have evolved from mechanisms of navigation in the physical world and hypothesize that the neuronal algorithms underlying navigation in real and mental space are fundamentally the same.
Journal ArticleDOI
Functional organization of the hippocampal longitudinal axis
TL;DR: Together, anatomical studies and electrophysiological recordings in rodents suggest a model in which functional long-axis gradients are superimposed on discrete functional domains, which provides a potential framework to explain and test the multiple functions ascribed to the hippocampus.
Journal ArticleDOI
Internally Generated Cell Assembly Sequences in the Rat Hippocampus
TL;DR: It is hypothesize that neuronal representations, evolved for encoding distance in spatial navigation, also support episodic recall and the planning of action sequences.
Journal ArticleDOI
Perineuronal nets stabilize the grid cell network
Ane Charlotte Christensen,Kristian Kinden Lensjø,Mikkel Elle Lepperød,Svenn-Arne Dragly,Hallvard Sutterud,Jan Sigurd Blackstad,Marianne Fyhn,Torkel Hafting +7 more
TL;DR: It is shown that removal of perineuronal nets leads to lower inhibitory spiking activity, and reduces grid cells’ ability to create stable representations of a novel environment, and that PNN removal in entorhinal cortex distorted spatial representations in downstream hippocampal neurons.
References
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The Hippocampus as a Cognitive Map
John O'Keefe,Lynn Nadel +1 more
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Book
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TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.