Journal ArticleDOI
The hydrolysis of hydrocortisone phosphate in essentially neutral solutions.
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The degradation of hydrocortisone phosphate in essentially neutral solutions appears to involve hydrolysis as the only significant degradative pathway and an equation expressing the effect of both temperature and pH on the rate of the reaction is presented.Abstract:
The degradation of hydrocortisone phosphate in essentially neutral solutions appears to involve hydrolysis as the only significant degradative pathway. The reaction is first order with respect to the steroid ester and seems linearly dependent upon the hydrogen ion concentration. The reaction is apparently an unusual 0.44 order with respect to the catalyst. The activation energy for the overall reaction has been found to be 17.0 ± 0.5 Kcal./mole. The “frequency factor” of the Arrhenius equation has been calculated and an equation expressing the effect of both temperature and pH on the rate of the reaction is presented.read more
Citations
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Economic evaluations of clinical pharmacy services: 2006-2010.
Daniel R. Touchette,Fred Doloresco,Katie J. Suda,Alexandra Perez,Stuart J. Turner,Yash J. Jalundhwala,Maria C. Tangonan,James M. Hoffman +7 more
TL;DR: The quality of economic evaluations of CPS published between 2006 and 2010 were described and evaluated to inform administrators and practitioners as to their cost‐effectiveness, and CPS were generally considered cost‐effective or provided a good benefit‐cost ratio.
Journal ArticleDOI
Pharmacist Interventions to Improve Cardiovascular Disease Risk Factors in Diabetes: A systematic review and meta-analysis of randomized controlled trials
Valérie Santschi,Valérie Santschi,Arnaud Chiolero,Arnaud Chiolero,Gilles Paradis,Gilles Paradis,April L. Colosimo,Bernard Burnand +7 more
TL;DR: A systematic review and meta-analysis of randomized controlled trials (RCTs) assesses the effect of pharmacist care on cardiovascular disease risk factors among outpatients with diabetes as discussed by the authors.
Pharmacist Interventions to Improve Cardiovascular Disease Risk Factors in
TL;DR: This meta-analysis supports pharmacist interventions—alone or in collaboration with other health care professionals—to improve major CVD risk factors among outpatients with diabetes.
Journal ArticleDOI
Impact of disease management programs on healthcare expenditures for patients with diabetes, depression, heart failure or chronic obstructive pulmonary disease: a systematic review of the literature.
TL;DR: Although it is widely believed that disease management programs reduce healthcare expenditures, the present study shows that evidence for this claim is still inconclusive and well-designed economic evaluations should be stimulated.
Journal ArticleDOI
A Systematic Review of the Evidence Concerning the Economic Impact of Employee-Focused Health Promotion and Wellness Programs
TL;DR: Evidence regarding economic impact of worker health promotion programs is limited and inconsistent and higher-quality research is needed to demonstrate the value of specific programs.
References
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Journal ArticleDOI
A quantitative color reaction for cortisone and related 17,21-dihydroxy-20-ketosteroids
Curt C. Porter,Robert H. Silber +1 more
TL;DR: Another test which appears to be specific for 17,21-dihydroxy-20-ketosteroids is added, based upon the appearance of a yellow color in solutions containing the steroid, phenylhydrazine, and sulfuric acid.
Journal ArticleDOI
The Lanthanum Hydroxide Gel Promoted Hydrolysis of Phosphate Esters
W. W. Butcher,F. H. Westheimer +1 more
Journal ArticleDOI
The Hydrolysis of Mono- and Dibenzyl Phosphates
Junji Kumamoto,F. H. Westheimer +1 more