Journal ArticleDOI
The influence of single and chronic morphine administration on some central effects of amphetamine and apomorphine.
TLDR
In experiments on mice acute toxicity of morphine did not differ in aggregated and non-aggregated animals and the development of tolerance to morphine affected differently the duration of the stereotypies produced by amphetamine and apomorphine.Abstract:
In experiments on mice acute toxicity of morphine did not differ in aggregated and non-aggregated animals. Morphine in doses of 5, 10, 20, 40, 80 mg/kg s.c. did not significantly influence the amphetamine group toxicity in mice.read more
Citations
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Book ChapterDOI
Pharmacology and neurochemistry of apomorphine.
TL;DR: This chapter discusses the pharmacology and neurochemistry of apomorphine, which was first employed as a powerful emetic agent and is metabolized by O-glucuronidation, O-methylation, and, probably, by N-demethylation.
Book ChapterDOI
Apomorphine: chemistry, pharmacology, biochemistry.
TL;DR: It is concluded that the 10, 11-dihydroxy substitution pattern of APO is an absolute requirement for optimal activity.
Book ChapterDOI
Neuropharmacology and Neurochemistry of Subjective Effects, Analgesia, Tolerance, and Dependence Produced by Narcotic Analgesics
W. R. Martin,J. W. Sloan +1 more
TL;DR: The purposes of this chapter are to discuss the subjective effects and behavioral correlates, analgesia, and the tolerance and dependence-producing properties of the narcotic analgesics and to relate these changes to their abuse.
Book ChapterDOI
Apomorphine and Its Relation to Dopamine in the Nervous System
TL;DR: Apomorphine was synthesized from morphine over one hundred years ago and was soon recognized as a powerful emetic agent, but until recently little attention was paid to its stereotypic properties with the exception of the work of Morita and Amsler (1923).
Journal ArticleDOI
Role of brain noradrenaline in morphine-induced stereotyped behaviour.
I. H. Ayhan,A. Randrup +1 more
TL;DR: Comparison between morphine and amphetamine stereotypy indicated that brain noradrenaline plays a more important role than dopamine in morphine induced stereotyped behaviour, in contrast to amp methamphetamine stereotypy where dopamine is the most important brain amine.
References
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Journal ArticleDOI
The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs.
TL;DR: The presence of noradrenaline and adrenaline in the brain has been demonstrated by von Euler and Holtz and the question whether these sympathomimetic amines, besides their role as transmitters at vasomotor endings, play a part in the function of the central nervous tissue itself is concerned.
Journal ArticleDOI
Mode of action of apomorphine and dexamphetamine on gnawing compulsion in rats.
TL;DR: The action of apomorphine on gnaw compulsion is, just as that of dopamine, directly on effect receptors, and may act as a substitute for dopamine deficiency in Parkinson's disease.
Journal Article
Metabolism of norepinephrine in the central nervous system
TL;DR: In the past few years a great deal of information has accumulated about the distribution and metabolism of catecholamines in the central nervous system, owing largely to new experimental approaches, and certain conclusions are possible about the actions of several important pharmacological agents on norepinephrine metabolism.
Journal Article
Tolerance to morphine. i. effects on catecholamines in the brain and adrenal glands
E. W. Maynert,Gerda I. Klingman +1 more
TL;DR: In dogs, rats and rabbits large doses of morphine caused less sedation than smaller doses but greater decreases in brain stem norepinephrine and adrenal catecholamines, and animals made tolerant to the sedative action of morphine by the subchronic administration of drug had normal levels of brain and Adrenal ctcholamines.
Related Papers (5)
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