Showing papers in "European Journal of Pharmacology in 1972"

TL;DR: Analysis of interactions between each of these cataleptogenic agents and naloxone, 1-DOPA and apomorphine strongly suggests that morphine influences striatal dopamine metabolism and produces catalepsy by a mechanism different from that of chlorpromazine.

TL;DR: Uptake was also inhibited by certain methoxylated phenylethylamine derivatives, but was unaffected by cocaine, desipramine, amitriptyline, angiotensin, histamine, ethanol or prostaglandins.

TL;DR: Evidence is given that ET495 or a derivative thereof is a central DA receptor stimulating agent with prolonged action and which may cause less hyperkinesias than apomorphine and DOPA and may represent a new tool in treatment of Parkinson's disease.

TL;DR: The results suggest that the effect on normetanephrine and 3-methoxytyramine in this biochemical test is correlated with catecholamine-releasing properties of the central stimulant drugs and not with an influence on the reuptake mechanism in catechlamine neurons.

TL;DR: The irreversible tryptophan hydroxylase inhibitor, p-chlorophenylalanine, decreases the brain level of 5-hydroxytryptamine; however, this effect has disappeared 2 weeks after injection.

TL;DR: An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, did not affect the actions of either amphetamine or fenfluramine.

TL;DR: The results point to a participation of 5-HT and dopamine in the central mediation of antinociceptive drug effects.

TL;DR: The results suggest that 5-MeO-DMT can directly stimulate central 5-HT receptors, and a capacity to stimulate 5- HT receptors seems to be a common property of hallucinogens of the indolealkylamine type.

TL;DR: It is suggested that β-bungarotoxin in addition to blocking transmitter release blocks the release of trophic substances from the nerve or alternatively that neuromuscular transmission and resulting muscle activity constitute trophics influences necessary for the prevention of the appearance of denervation changes.

TL;DR: It was concluded that apomorphine increases the motility in rats by direct stimulation of dopamine receptors but another factor is also of importance: noradrenergic neurotransmission.

TL;DR: It is concluded that vagal reflex bradycardia is facilitated by an action of clonidine on α-receptors within the central nervous system, since the facilitatory effect was decreased by α-adrenoceptor blocking agents.

TL;DR: The effect of 6-OH-DA was selective since brain concentrations of serotonim (5-HT), acetylcholine (ACh), γ-aminobutyric acid (GABA), glutamic acid, glycine and several other amino acids were not significantly altered by such treatment and the depletion of brain catecholamines was accompanied by various behavioural changes.

TL;DR: Insulin exerts a direct positive inotropic effect upon canine heart muscle depressed by propranolol or due to prolonged incubation, and the effect is not dependent upon catecholamines, glucagon or glucose.

TL;DR: It is concluded that clonidine acts in the central nervous system to enhance vagally mediated reflex bradycardia in dogs anaesthetized with pentobarbital and artificially ventilated.

TL;DR: It is suggested that apomorphine stereotypy is not mediated via a direct action upon the dopamine receptor, but requires an effective nigro-striatal dopaminergic system and the mechanism involved in spontaneous stereotypy are not the same as those of the drug-induced state.

TL;DR: It was concluded that α-methyldopa exerts its blood pressure decreasing effect at least partly by the stimulation of central α-sympathetic receptors.

TL;DR: Evidence is presented which suggests that the modified response is a consequence of stimulation of DA receptor that are more sensitive to apomorphine as a consequences of 6-HDA treatment.

TL;DR: Electrochemical and chemical studies show that 6-hydroxydopamine does not oxidize in vitro at physiological pH to the cyclized indoline (aminochrome) as previously believed.

TL;DR: In vivo experiments on rat mesenteric arterioles demonstrate that dose—response curves for the constrictor catecholamines epinephrine and norepinephrine in female rats are significantly shifted in a parallel manner to the left of those obtained in male rats, which could be interpreted as support for a role of sex hormones in control of blood flow.

TL;DR: Noradrenaline and tetrodotoxin prevented both release of acetylcholine and contraction of the intestine produced by gastrin and related polypeptides.

TL;DR: Results indicate the involvement of neuronal systems in both the striatum and pallidum with the production of amphetamine stereotypy and its inhibition by neuroleptic and cholinergic agents.

TL;DR: It is suggested that hydrocortisone augments vasoconstrictor responses to epinephrine by an action on adrenergic receptors by modifying dilator responses to isoproterenol.

TL;DR: It is concluded that α-adrenergic receptors in aortas from various mammalian species investigated must be of a single type.

TL;DR: The hypothesis that depolarizing agents elevate levels of cyclic AMP at least in part by a depolarization-evoked ‘release’ of adenosine, which then interacts with a regulatory unit for adenyl cyclase is supported.

TL;DR: Dipyridamole and hexobendine potentiate the inhibitory responses of the guinea-pig isolated taenia coli to both stimulation of non-adrenergic (‘purinergic’) inhibitory nerves and to exogenously applied ATP, consistent with the hypothesis that ATP is the transmitter released from purinergic inhibitory nerve in the gut.

TL;DR: The concept that β-receptor stimulation increases the rate of renin secretion and that this effect is mediated via the formation of cyclic AMP is supported.

TL;DR: The recent work of several investigators confirms the existence of a non-passive, saturable process for ascorbic acid absorption in man and values of Vmax and Km are calculated using the equations of saturable absorption kinetics.

TL;DR: A critical role of brain monoamines and the striopallidothalamic system in the production of oral myoclonic activity in the rat is suggested and evidence for a serotoninergic mechanism in the lower brain stem has been obtained.

TL;DR: Both potentiated L-dopa and 5-HT in doses producing uptake inhibition although potentiation of L- dopa by chlorimipramine was greater than expected from its inhibition of the uptake of noradrenaline.

TL;DR: It is concluded that only a small portion of tissue NE content is sufficient for development and maintenance of hypertension in the SHR.