The level of free choline in plasma

TLDR: Previous assays of free choline in blood, plasma and serum are summarized, and shows a wide scatter of values ranging from l to 75,ug/ml, suggesting that such a wide range of values is unlikely.

Abstract: Although numerous attempts have been made to estimate the amount of free choline present in blood and tissue fluids, there is little consistency in the results obtained. Table 1 summarizes previous assays of free choline in blood, plasma and serum, and shows a wide scatter of values ranging from l to 75,ug/ml. The effect of quite small doses of choline hydrochloride upon blood pressure (Dale, 1914) and the recent observation by Hutter (1952) that an intravenous injection of as little as 2 mg of choline hydrochloride per kg body weight has an effect upon neuromuscular transmission in the cat, suggest that such a wide range of values is unlikely.