The Magic of Cluster SIMS
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TLDR
Low topography, enhanced high-mass ion yields, and low damage cross sections have researchers thinking about new applications that may lead to the discovery of new biology.Abstract:
Low topography, enhanced high-mass ion yields, and low damage cross sections have researchers thinking about new applications that may lead to the discovery of new biology.read more
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Journal ArticleDOI
Lipid rafts: at a crossroad between cell biology and physics.
TL;DR: The concept of lipid rafts as it has emerged from the study of synthetic membranes with the reality of lateral heterogeneity in biological membranes is compared.
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Sublimation as a Method of Matrix Application for Mass Spectrometric Imaging
TL;DR: MALDI matrix could be readily applied to tissue sections on glass slides and stainless steel MALDI plate inserts as long as good thermal contact was made with the condenser of the sublimation device and the method was reproducible and eliminated the potential for spreading of analytes arising from solvent deposition during matrix application.
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Clathrate nanostructures for mass spectrometry
Trent R. Northen,Oscar Yanes,Michael T. Northen,Dena Marrinucci,Winnie Uritboonthai,Junefredo V. Apon,Stephen L. Golledge,Anders Nordström,Gary Siuzdak +8 more
TL;DR: NIMS uses ‘initiator’ molecules trapped in nanostructured surfaces or ‘clathrates’ to release and ionize intact molecules adsorbed on the surface to allow direct characterization of peptide microarrays, direct mass analysis of single cells, tissue imaging, anddirect characterization of blood and urine.
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Droplet Dynamics and Ionization Mechanisms in Desorption Electrospray Ionization Mass Spectrometry
TL;DR: A droplet pickup and other mechanisms have been suggested for the ionization of biomolecules like peptides and proteins by desorption electrospray ionization to verify this hypothesis phase Doppler particle analysis was used to study the sizes and velocities of droplets involved in DESI.
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TOF-SIMS 3D Biomolecular Imaging of Xenopus laevis Oocytes Using Buckminsterfullerene (C60) Primary Ions
TL;DR: This is the first demonstration of the 3D biomolecular imaging within an actual biological system using TOF-SIMS with a freeze-dried Xenopus laevis oocyte, which is a single cell.