Journal ArticleDOI
The nephrotic syndrome associated with secondary syphilis: An immune deposit disease
TLDR
The findings suggest that acute syphilitic nephrosis is an immune deposit disease that developed during the course of secondary syphilis.About:
This article is published in The American Journal of Medicine.The article was published on 1970-05-01. It has received 82 citations till now. The article focuses on the topics: Glomerular mesangial cell proliferation & Nephrosis.read more
Citations
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Book ChapterDOI
Immune Complex Disease in Experimental Animals and Man
Charles G. Cochrane,D Koffler +1 more
TL;DR: This chapter summarizes the data presented in two reviews of experimental acute and chronic immune complex disease produced by nonliving antigens and discusses in detail more recent studies.
Book ChapterDOI
The Biology and Detection of Immune Complexes
TL;DR: This chapter describes the interaction of immune complexes (ICs) with complement and with the cells of the immune system, thereby making it possible to identify the antigens involved in immune processes of a great many diseases, including those of unknown etiology.
Journal ArticleDOI
Long-term prognosis of idiopathic membranous glomerulonephritis: Study of 116 untreated patients
TL;DR: Patients with idiopathic membranous glomerulonephritis were studied to evaluate their clinical course and long-term prognosis, and the mean interval between discovery of the disease and renal biopsy according to the type of glomerular lesions, is shorter in patients with type I lesions than in those with type II and III lesions.
Journal ArticleDOI
Immunopathogenesis of syphilitic glomerulonephritis. Elution of antitreponemal antibody from glomerular immune-complex deposits.
TL;DR: A renal biopsy was performed on a patient with syphilitic glomerulonephritis characterized clinically by the acute onset of nephrosis that responded dramatically to penicillin therapy, indicating that the glomerular injury occasionally complicating secondary syphilis is due to the deposition of trep onemal antigen-antitreponemal antibody complexes.
Journal ArticleDOI
Gamma G globulin subgroup composition of the glomerular deposits in human renal diseases.
TL;DR: The selective deposition of monotypic or restricted gammaG subgroups on the glomerulus supports the likelihood that the gammaG represents antibody in human glomerulonephritis.
References
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Journal ArticleDOI
Immunological studies concerning the nephritis of systemic lupus erythematosus
TL;DR: The immunochemical evidence for the high specific activity of antinuclear antibodies and the association of DNA antigen with DNA antibody in glomeruli add further support for the antigen-antibody complex hypothesis for renal injury in systemic lupus erythematosus.
Journal ArticleDOI
A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis.
TL;DR: Controls indicated that the polymorph depleted animals exhibited minimal non-specific changes in the blood, that the ability of their vascular beds to react to stimuli was not affected, and that deposition of nephrotoxic antibody and C' in the glomeruli was not inhibited, indicating that a polymorph independent glomerular injury may also take place in first stage neph Rotoxic nephritis.
Book ChapterDOI
Experimental glomerulonephritis: immunological events and pathogenetic mechanisms.
Emil R. Unanue,Frank J. Dixon +1 more
TL;DR: It is now possible to account qualitatively and sometimes even quantitatively for the glomerular changes in two forms of experimental nephritis—namely, those due to nephrotoxic serum and to circulating antigen-antibody complexes.
Journal ArticleDOI
Renal immune deposits in scleroderma.
TL;DR: The results support the hypothesis that circulating immune complexes are an important factor in the development of renal disease in scleroderma patients and immunosuppressive therapy might be of value in such patients.
Related Papers (5)
Immunopathogenesis of syphilitic glomerulonephritis. Elution of antitreponemal antibody from glomerular immune-complex deposits.
Nephropathy of secondary syphilis. A clinical and pathological spectrum.
Evidence for soluble immune complexes in the pathogenesis of the glomerulonephritis of quartan malaria
PeterA. Ward,JohnW. Kibukamusoke +1 more