Journal ArticleDOI
The oxidative environment and protein damage
TLDR
The major fate of oxidised proteins is catabolism by proteosomal and lysosomal pathways, but some materials appear to be poorly degraded and accumulate within cells, and the accumulation of such damaged material may contribute to a range of human pathologies.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2005-01-17. It has received 1230 citations till now. The article focuses on the topics: Protein oxidation & Methionine sulfoxide.read more
Citations
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Journal ArticleDOI
Oxidative stress and neurodegeneration: where are we now?
TL;DR: After a long lag period, therapeutic and other interventions based on a knowledge of redox biology are on the horizon for at least some of the neurodegenerative diseases.
Journal ArticleDOI
Biomarkers of Oxidative Damage in Human Disease
TL;DR: Some of the more commonly used biomarkers of oxidative/nitrosative damage are discussed and selected examples of human studies are included.
Journal ArticleDOI
Cellular Defenses against Superoxide and Hydrogen Peroxide
TL;DR: Bacteria comprise an exceptionally accessible experimental system that has provided many of the answers to the remaining puzzles in an anaerobic world, and current research seeks to identify these.
Journal ArticleDOI
ROS signalling in the biology of cancer.
TL;DR: The generation and sources of ROS within tumour cells, the regulation of ROS by antioxidant defence systems, as well as the effect of elevated ROS production on their signalling targets in cancer are discussed.
Journal ArticleDOI
Antioxidant Activity of Proteins and Peptides
TL;DR: While proteins and peptides have excellent potential as food antioxidants, issues such as allergenicity and bitter off-flavors as well as their ability to alter food texture and color need to be addressed.
References
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Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Critical Review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals (⋅OH/⋅O− in Aqueous Solution
TL;DR: In this article, the rate constants for over 3500 reaction are tabulated, including reaction with molecules, ions and other radicals derived from inorganic and organic solutes, and the corresponding radical anions, ⋅O− and eaq−, have been critically pulse radiolysis, flash photolysis and other methods.
Journal Article
Critical review of rate condtants for reaction of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution
Journal ArticleDOI
Rate Constants for Reactions of Inorganic Radicals in Aqueous Solution
TL;DR: In this article, rate constants have been compiled for reactions of various inorganic radicals produced by radiolysis or photolysis, as well as by other chemical means in aqueous solutions.
Book ChapterDOI
Carbonyl assays for determination of oxidatively modified proteins
TL;DR: New methods for determination ofcarbonyl content are presented, which are based on the reaction of carbonyl groups with 2,4-dinitrophenylhydrazine to form a 2, 4-d Initrophenolhydrazone, which provide substantial improvements in both sensitivity and specificity.