Journal ArticleDOI
The potency and antigen E content of commercially prepared ragweed extracts
Harold Baer,Harold Baer,Henry P. Godfrey,Henry P. Godfrey,Clifford J. Maloney,Clifford J. Maloney,Philip S. Norman,Philip S. Norman,Lawrence M. Lichtenstein,Lawrence M. Lichtenstein +9 more
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TLDR
Results indicate that double diffusion determinations of antigen E content would be a satisfactory method for the standardization of the potency of ragweed pollen allergenic extracts.About:
This article is published in Journal of Allergy.The article was published on 1970-06-01. It has received 115 citations till now.read more
Citations
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Journal ArticleDOI
Allergen immunotherapy: A practice parameter third update
Linda Cox,Harold S. Nelson,Richard F. Lockey,Christopher W. Calabria,Thomas Chacko,Ira Finegold,M.R. Nelson,Richard W. Weber,David I. Bernstein,Joann Blessing-Moore,David A. Khan,David M. Lang,Richard A. Nicklas,John Oppenheimer,Jay M. Portnoy,Christopher Randolph,Diane E. Schuller,Sheldon L. Spector,Stephen A. Tilles,Dana Wallace +19 more
TL;DR: These parameters were developed by the Joint Task Force on Practice Parameters, representing the American Academy of Allergy, Asthma & Immunology (AAAAI); the American Col- lege of Allergen,Asthma & immunology (ACAAI); and the Joint Council of All allergy, asthma, and Immunology.
Journal ArticleDOI
Ragweed immunotherapy in adult asthma.
Peter S. Creticos,Charles E. Reed,Philip S. Norman,Jane Khoury,N. F. Adkinson,Charles R. Buncher,William W. Busse,Robert K. Bush,Gadde J,James T. Li +9 more
TL;DR: Although immunotherapy for adults with asthma exacerbated by seasonal ragweed exposure had positive effects on objective measures of asthma and allergy, the clinical effects were limited and many were not sustained for two years.
Journal ArticleDOI
Allergen immunotherapy: a practice parameter
TL;DR: This parameter was edited by Dr. Nicklas in his private capacity and not in his capacity as a medical officer with the United States Food and Drug Administration (FDA).
Book ChapterDOI
Allergens and the Genetics of Allergy
TL;DR: It has been shown that, other than a tendency for allergens to be at the lower end of the molecular weight spectrum of antigens, there is no general chemical feature that characterizes allergens as a subpopulation of ants.
Journal ArticleDOI
Diagnostic tests in ragweed hay fever. A comparison of direct skin tests, IgE antibody measurements, and basophil histamine release.
TL;DR: The RAST is a quantitative technique that gives diagnostically useful information in ragweed hay fever, although not significantly different from basophil histamine release or carefully performed skin testing, and the convenience to the patient may, however, offer a noticeable advantage.
References
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Journal ArticleDOI
Studies on the mechanisms of hypersensitivity phenomena. ix. histamine release from human leukocytes by ragweed pollen antigen.
TL;DR: It has been proposed that immunologically induced histamine release is an active, enzymatically mediated process which occurs as a multistep response of viable cells to a specific antigenic stimulus.
Journal ArticleDOI
Isolation and characterization of allergens from ragweed pollen. ii.
Journal ArticleDOI
Studies on the mechanism of hypersensitivity phenomena. II. The participation of complement in passive cutaneous anaphylaxis of the albino rat.
TL;DR: The data presented indicate that the PCA reaction can be studied as a function of at least three variables, antigen, antibody, and a serum constituent resembling C'.
Journal ArticleDOI
Immunotherapy of hay fever with ragweed antigen E: comparisons with whole pollen extract and placebos.
TL;DR: It seems likely that a major proportion of the desensitizing effect of whole extract can be attributed to antigen E, which was well tolerated by ragweed-sensitive patients, giving fewer systemic and local reactions than whole extract.
Journal ArticleDOI
The allergen content of pollen extracts. Its determination and its deterioration
TL;DR: The protein nitrogen content of pollen extracts can be determined directly by analysis of the 10 per cent phosphotungstic acid protein precipitate or indirectly by the difference between the total and nonprotein nitrogen as mentioned in this paper.