Journal ArticleDOI
Diagnostic tests in ragweed hay fever. A comparison of direct skin tests, IgE antibody measurements, and basophil histamine release.
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TLDR
The RAST is a quantitative technique that gives diagnostically useful information in ragweed hay fever, although not significantly different from basophil histamine release or carefully performed skin testing, and the convenience to the patient may, however, offer a noticeable advantage.Abstract:
In 87 patients with both spring and fall hay fever symptoms the radioallergosorbent test (RAST) technique for specific IgE antibodies to ragweed was compared with basophil histamine release and direct intradermal skin testing by the threshold dilution technique. The three techniques gave good agreement except with the leastsensitive patients, some of whom had a positive skin test but undetectable histamine release or IgE antibodies. Twenty-one patients who were highly sensitive to ragweed as measured by all three techniques were followed without specific immunotherapy. There was significant agreement between the level of positivity of all three tests and the symptom index obtained during the ragweed season. In 14 of the 21 patients there was a significant correlation between daily ragweed pollen counts and daily symptom indexes during the season. On the other hand, among the 16 least-sensitive patients (as judged by histamine release) the correlation between daily ragweed pollen counts and symptom indexes was significant in only 3 patients. Other significant allergens could not be identified in the latter group, and the cause of their symptoms is not clearly identified but appears not to be ragweed. The RAST is a quantitative technique that gives diagnostically useful information in ragweed hay fever, although not significantly different from basophil histamine release or carefully performed skin testing. The convenience to the patient may, however, offer a noticeable advantage.read more
Citations
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Journal ArticleDOI
The diagnosis and management of rhinitis: An updated practice parameter
Dana Wallace,Mark S. Dykewicz,David I. Bernstein,Joann Blessing-Moore,Linda Cox,David A. Khan,David M. Lang,Richard A. Nicklas,John Oppenheimer,Jay M. Portnoy,Christopher Randolph,Diane E. Schuller,Sheldon L. Spector,Stephen A. Tilles +13 more
TL;DR: This document incorporated the efforts of many participants, and no single individual, including those who served on the Joint Task Force, is authorized to provide an official AAAAI or ACAAI interpretation of these practice parameters.
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Allergy diagnostic testing: An updated practice parameter
I. Leonard Bernstein,James T. Li,David I. Bernstein,Robert G. Hamilton,Sheldon L. Spector,Ricardo A. Tan,Scott H. Sicherer,David B.K. Golden,David A. Khan,Richard A. Nicklas,Jay M. Portnoy,Joann Blessing-Moore,Linda Cox,David M. Lang,John Oppenheimer,Christopher Randolph,Diane E. Schuller,Stephen A. Tilles,Dana Wallace,Estelle Levetin,Richard W. Weber +20 more
TL;DR: This dissertation aims to provide a history of musical criticism dating back to the publication of T.I. Bernstein's "lost symphony" (1962) and investigates its roots in classical criticism and its application to modern music.
Journal ArticleDOI
Fatalities from immunotherapy (IT) and skin testing (ST)
Richard F. Lockey,Richard F. Lockey,Richard F. Lockey,Linda M. Benedict,Linda M. Benedict,Linda M. Benedict,Paul C. Turkeltaub,Paul C. Turkeltaub,Paul C. Turkeltaub,Samuel C. Bukantz,Samuel C. Bukantz,Samuel C. Bukantz +11 more
TL;DR: The Committee on Allergen Standardization of the American Academy of Allergy and Immunology obtained information about 46 fatalities that had occurred during immunotherapy (IT) or skin testing (ST) since 1945, finding the risk of a fatal reaction is low and may be lessened even further as additional precautions are taken.
Journal ArticleDOI
The prevalence of allergic skin test reactivity to eight common aeroallergens in the U.S. population: Results from the second National Health and Nutrition Examination Survey
TL;DR: Skin test reactivity increased in both whites and blacks with increasing income and education, and in blacks, the most important predictors were age, urban residence, and poverty status.
Journal ArticleDOI
HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from natural antigenic exposure.
David G. Marsh,Susan H. Hsu,Marianne Roebber,Eva Ehrlich-Kautzky,Linda R. Freidhoff,Deborah A. Meyers,M K Pollard,Wilma B. Bias +7 more
TL;DR: Qualitative responses to Ra5 in both groups were found to be strongly associated with HLA-Dw2, and the primary association of Ra5 response was with Dw2 rather than DR2 and that various combinations of A3, B7, and Dw2 were less strongly associated than Dw2 alone.
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