Journal ArticleDOI
The stability of ascorbic acid in various liquid media
F.J. Bandelin,J.V. Tuschhoff +1 more
TLDR
Ascorbic acid was relatively stable in glycerin and propylene glycol and in sugar and sorbitol solutions and in syrups containing conjointly vitamins of the B‐complex is not materially affected.Abstract:
The stability of ascorbic acid at several concentrations in various liquid media including aqueous solutions of cellulose gums, pectin, sucrose, dextrose, corn syrup, and in glycerin and propylene glycol was studied The effect of p H in aqueous solutions of ascorbic acid was also studied Viscosity alone as produced by gums did not prevent decomposition of ascorbic acid Sugar and sorbitol solutions exerted a marked stabilizing effect Ascorbic acid was relatively stable in glycerin and propylene glycol and in sugar and sorbitol solutions Data are presented on the rates of decomposition of ascorbic acid in these media after storage at room temperature and at 40°C The stability of ascorbic acid in syrups containing conjointly vitamins of the B‐complex is not materially affectedread more
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Journal ArticleDOI
Gravimetric analysis and differential scanning calorimetric studies on glycerin-induced skin hydration.
Ae-Ri Cho Lee,Hee Kyung Moon +1 more
TL;DR: High diffusivity induced by the hydration effect of glycerin and water could be the major contributing factor for the enhanced skin permeation of nicotinic acid (NA).
Journal ArticleDOI
The stability of vitamin C in a commercial fruit squash.
TL;DR: In this paper, the deterioration of vitamin C in a fruit squash was followed during storage under the conditions encountered in normal commercial practice, and the initial level of 32 mg. of natural vitamin C per 100 ml was maintained for 6 months; 80% was retained after 12 months, 50-60% after 18 months and about 40% after 2 years.
Journal ArticleDOI
Direct or indirect skin lipid-ordering effect of pyrrolidone carboxylate sodium after topical treatment with penetration enhancers.
TL;DR: The structural changes in the lipid of the excised skin of nude mice and the porcine stratum corneum was investigated by in vitro treatment with vitamin C, oleic acid, or DMSO, and the spectral shift of the asymmetric CH2 band was more sensitive than that of the symmetricCH2 band.
Journal ArticleDOI
Influence of DL-Methionine on the Photostability of Ascorbic Acid Solutions
Ahmed F. Asker,D. Canady,C. Cobb +2 more
TL;DR: The photostablizing effect of DL-methionine for various buffered solutions of ascrobic acid was investigated and it was found to enhance the photostability of 40 mg% ascorbic acid in acetate and phosphate buffers, but not in citrate buffer of pH 4.5.
Journal ArticleDOI
Topical delivery of 3-O-ethyl l-ascorbic acid from complex solvent systems
Fotis Iliopoulos,A. S. M. Monjur Al Hossain,Bruno C. Sil,David J. Moore,Robert Anthony Lucas,Majella E. Lane +5 more
TL;DR: In this paper, the authors designed complex formulations using combinations of solvents that may act synergistically and examined their impact on EA permeation in porcine skin in vitro under finite dose conditions.