Journal ArticleDOI
The Synergistic Effects of Different Radiations
M. Zaider,Harald H. Rossi +1 more
TLDR
Theoretical expressions, based on the Theory of Dual Radiation Action, are derived to calculate the effects of mixed radiation exposures on survival distributions and indicate the synergistic effect of sequential exposures due to the interaction between sublesions produced by the different types of radiation.Abstract:
Theoretical expressions, based on the Theory of Dual Radiation Action, are derived to calculate the effects of mixed radiation exposures on survival distributions. Temporal effects (such as recovery from sublethal injury) are explicitly included in the calculations. The results indicate the synergistic effect of sequential exposures due to the interaction between sublesions produced by the different types of radiation.read more
Citations
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Journal ArticleDOI
Irradiation of Mixed Beam and Design of Spread-Out Bragg Peak for Heavy-Ion Radiotherapy
Tatsuaki Kanai,Yoshiya Furusawa,Kumiko Fukutsu,Hiromi Itsukaichi,Kiyomi Eguchi-Kasai,Hiroshi Ohara +5 more
TL;DR: The results indicated that the dose-cell survival relationship for the combined high- and low-LET beams could be described by a linear-quadratic (LQ) model, in which new coefficients alpha and beta forThe combined irradiation were obtained in terms of dose-averaged alpha and square root of beta for the single irradiation with monoenergetic beams.
Journal ArticleDOI
Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams
Yuki Kase,Tatsuaki Kanai,Tatsuaki Kanai,Yoshitaka Matsumoto,Yoshiya Furusawa,Okamoto Hiroyuki,Toru Asaba,Makoto Sakama,Hiroshi Shinoda +8 more
TL;DR: The estimated α terms of the liner-quadratic model with a fixed β value reproduced the experimental results for cell irradiation for ion beams with LETs of less than 450 keV/μm, except in the region near the distal peak.
Journal ArticleDOI
The FLUKA Code: An Accurate Simulation Tool for Particle Therapy.
Giuseppe Battistoni,Julia Bauer,T.T. Boehlen,Francesco Cerutti,M. P. W. Chin,R.S. Augusto,R.S. Augusto,Alfredo Ferrari,Pablo G. Ortega,Wioletta Kozlowska,Wioletta Kozlowska,Giuseppe Magro,Andrea Mairani,Katia Parodi,Paola Sala,P. Schoofs,Thomas Tessonnier,V. Vlachoudis +17 more
TL;DR: Refinements of the FLUKA nuclear models in the therapeutic energy interval lead to an improved description of the mixed radiation field as shown in the presented benchmarks against experimental data with both 4He and 12C ion beams.
Journal ArticleDOI
A phenomenological model for the relative biological effectiveness in therapeutic proton beams.
Jan J. Wilkens,Uwe Oelfke +1 more
TL;DR: A simple phenomenological model is proposed that describes the RBE as a function of the dose, the linear energy transfer (LET) and tissue specific parameters and has therefore potential applications in iterative treatment planning for proton therapy.
Journal ArticleDOI
Development of the open-source dose calculation and optimization toolkit matRad.
Hans-Peter Wieser,Eduardo Cisternas,Niklas Wahl,Silke Ulrich,Alexander Stadler,Henning Mescher,Lucas-Raphael Müller,Thomas Klinge,Hubert Gabrys,Lucas Burigo,Andrea Mairani,Swantje Ecker,Benjamin Ackermann,Malte Ellerbrock,Katia Parodi,Oliver Jäkel,Mark Bangert +16 more
TL;DR: The dosimetric accuracy, computational performance and open‐source character of matRad encourages a future application of the toolkit for both educational and research purposes.
References
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Journal ArticleDOI
Sublethal damage in cells of the mouse gut after mixed treatment with X rays and fast neutrons.
TL;DR: The results show that cells surviving the first dose of radiation have accumulated the same amount of recoverable sublethal damage regardless of whether that first dose was with X rays or neutrons, so the combined effect is simply additive.