Journal ArticleDOI
Time-related binding of the hepatocarcinogen carbon tetrachloride to hepatic chromatin proteins in vitro.
TLDR
Different extents of alkylation or acylation between histones and NHCP by metabolically activated CCl4 under aerobic in vitro conditions are suggested, and differential inhibition of CCl 4-alkylation-acylation by cysteine is suggested.Citations
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Journal ArticleDOI
Oral contraceptives and colorectal tumors. A review of epidemiologic studies.
TL;DR: It seems that OC use does not increase and may even have a favorable effect on either incidence or mortality of colorectal cancer.
Journal ArticleDOI
The role of metabolism in carbon tetrachloride-mediated immunosuppression. In vitro studies.
TL;DR: It is concluded that immunotoxicity by CCl4 requires metabolic activation and pretreatment of mice with inducers and inhibitors of the mixed function oxygenase system prior to CCl 4 administration modulated the immunotoxic effects of C Cl4 in vivo.
Effects of shrimp contaminated with cyanobacterial toxins on hepatic cytoplasmic proteins and mitochondrial redox state in albino rats
TL;DR: The results suggest the probable interference of the toxin with redox reaction pathway in the mitochondria and inhibition of cytoplasmic protein in rats suggests potential hepato-toxicity to humans in the Niger Delta who consume these shrimps on a daily basis.
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