Tissue-Muscle Perfusion Scintigraphy of the Lower Limbs in a Patient with Type 2 Diabetes Mellitus and Peripheral Arterial Disease.
Nevena Manevska,Daniela Pop Gjorceva,Irfan Ahmeti,Lidija Todorovska,Sinisa Stojanoski,Marina Zdraveska Kocovska +5 more
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TLDR
A case of a 71-year-old male diabetic patient with skin ulcers of the right foot and an ankle-brachial index >1.2 and a noninvasive, functional method of 99mTc-MIBI (methoxy-isobutyl-isonitrile) tissue-muscle perfusion scintigraphy of the lower limbs, which assesses tissue perfusion in basal conditions and exercise conditions.Abstract:
The estimation of tissue perfusion as a hemodynamic consequence of peripheral arterial disease (PAD) in diabetic patients is of great importance in the management of these patients.We present a noninvasive, functional method of 99mTc-MIBI (methoxy-isobutyl-isonitrile) tissue-muscle perfusion scintigraphy (TMPS) of the lower limbs, which assesses tissue perfusion in basal conditions ("rest" study) and exercise conditions ("stress" study). Emphasis is given on perfusion reserve (PR) as an important indicator of preservation of microcirculation and its local autoregulatory mechanisms in PAD. We present a case of a 71-year-old male diabetic patient with skin ulcers of the right foot and an ankle-brachial index >1.2 (0.9-1.1). Dynamic phase TMPS of the lower limbs showed decreased and late arterial vascularization of the right calf (RC) with lower percentage of radioactivity in the 1st minute: RC 66%, left calf (LC) 84%. PR was borderline with a value of 57% for LC and decreased for RC (42%). Functional assessment of hemodynamic consequences of PAD is important in evaluating both advanced and early PAD, especially the asymptomatic form. The method used to determine the TMPS of the lower limbs, can differentiate subtle changes in microcirculation and tissue perfusion.read more
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Lateral parapatellar and subvastus approaches are superior to the medial parapatellar approach in terms of soft tissue perfusion
Aykut Koçak,Ahmet Özmeriç,Gökhan Koca,Mehmet Senes,Nihat Yumuşak,Serkan İltar,Meliha Korkmaz,Kadir Bahadır Alemdaroğlu +7 more
TL;DR: The LPPa and SVa caused less oxidative stress and less disruption of the muscle blood supply, in biochemical and scintigraphic parameters, compared to the MPPa and MVa, and should be preferred more frequently in selected cases with critical soft tissue viability.
Journal ArticleDOI
Perfusión tejido-músculo evaluada mediante protocolo de un día de gammagrafía reposo-dipiramidol con 99mTc-MIBI en pacientes no diabéticos y diabéticos
Nevena Manevska,Sinisha Stojanoski,D Pop Gjorceva,Lidija Todorovska,Marija Vavlukis,Venjamin Majstorov +5 more
TL;DR: La TMPS de miembros inferiores en nuestro estudio indico that la reserva de perfusion en pacientes con DM fue significativamente menor, en comparacion con los paciente sin diabetes.
Journal ArticleDOI
Normal Values of Tissue-Muscle Perfusion Indexes of Lower Limbs Obtained with a Scintigraphic Method.
Nevena Manevska,Sinisa Stojanoski,Daniela Pop Gjorceva,Lidija Todorovska,Daniela Miladinova,Beti Zafirova +5 more
TL;DR: This non-invasive scintigraphic method allows in individuals without peripheral artery disease to determine the range of normal values of muscle perfusion at rest and stress condition and to clinically implement them in evaluation of patients with peripheral artery Disease for differentiating patients with normal from those with impaired lower limbs circulation.
Journal ArticleDOI
Regional skeletal muscle perfusion distribution in diabetic feet may differentiate short-term healed foot ulcers from non-healed ulcers
Jie-Quan Zheng,Ran Li,Erin E Dickey,Yan Yan,Mohamed A. Zayed,Jennifer A. Zellers,Mary K. Hastings +6 more
TL;DR: In this article , the authors leverage a magnetic resonance imaging (MRI) approach to characterize foot perfusion distribution in patients with diabetes, with or without foot ulcers, and determine the ability of the regional perfusion measurements to identify ulcer-healing status.
Journal ArticleDOI
Perfusion, Stance and Plantar Pressure Asymmetries on the Human Foot in the Absence of Disease—A Pilot Study
TL;DR: In this paper , the authors explored potential relationships between perfusion and pressure variables in humans and found that significant correlations were found between BMI and mean Plantar Pressure in Phase I and Phase III, and an inverse correlation between LDF perfusion, plantar pressure and stance obtained by a pressure plate.
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