Journal ArticleDOI
Tofacitinib for the treatment of active ankylosing spondylitis in adults
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TLDR
Tofacitinib, a JAK inhibitor, has been shown to be effective in both phase II and phase III trials for the treatment of ankylosing spondylitis as discussed by the authors .Abstract:
Ankylosing spondylitis, also known as radiographic axial spondyloarthritis, is a complex, immune-mediated inflammatory disorder most commonly involving the spine including the sacroiliac joints.Complex pathogenesis of axial spondyloarthritis involving genetic, environmental, and both innate and adaptive immune systems. Treatment options for ankylosing spondylitis. Pharmacologic properties, efficacy, and safety of tofacitinib, a JAK inhibitor. Data regarding efficacy of approved JAK inhibitors in the treatment of ankylosing spondylitis, including tofacitinib, upadacitinib, and filgotinib.Current treatment options of ankylosing spondylitis include NSAIDs, TNFi, and IL-17i. JAK inhibitors present a new class of therapy that has shown efficacy in the treatment of active ankylosing spondylitis in adults. While it has not been directly compared to alternative therapies, tofacitinib has been shown to be effective in both phase II and phase III trials for the treatment of ankylosing spondylitis. While these trials did not show any significant difference from placebo in terms of safety, the ORAL Surveillance study showed tofacitinib to be inferior to TNFi when comparing adverse events. Thus, tofacitinib presents a viable treatment option for the management of AS, however shared decision-making regarding risks and benefits will be important. read more
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Journal ArticleDOI
A Comprehensive Overview of Globally Approved JAK Inhibitors
TL;DR: The data in the current review could help in the design of new JAK inhibitors with potential therapeutic benefits in inflammatory and autoimmune diseases.
Journal ArticleDOI
Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders.
TL;DR: The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2,JAK3, and TYK2 (Tyrosine Kinase 2).
Journal ArticleDOI
The genetic backbone of ankylosing spondylitis: how knowledge of genetic susceptibility informs our understanding and management of disease
TL;DR: In this paper , the impact of genetics on the understanding of ankylosing spondylitis and its relationship with closely linked pathologies is discussed, and the authors further explore how genetics can be used in the development of therapeutics and as a tool to assist in the diagnosis and management of patients.
Journal ArticleDOI
Effects of Isosakuranetin on Pharmacokinetic Changes of Tofacitinib in Rats with N-Dimethylnitrosamine-Induced Liver Cirrhosis
TL;DR: In this article , the effects of Isosakuranetin (ISN) on the pharmacokinetics of tofacitinib in rats with N-dimethylnitrosamine-induced liver cirrhosis (LC) were investigated.
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Molecular dissection of Janus kinases as drug targets for inflammatory diseases
TL;DR: In this article , the role of JAKs in the JAK-STAT signaling pathway and analyze their conformational changes for catalysis are discussed. And based on updated structural information on JAK, they also discuss strategies for disrupting the dimerization of jAKs to develop novel JAK inhibitors.
References
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Dysbiosis of the gut microbiota in disease
TL;DR: Data suggest that CNS-related co-morbidities frequently associated with GI disease may originate in the intestine as a result of microbial dysbiosis, and the potential to positively modulate the composition of the colonic microbiota and ameliorate disease activity through bacterial intervention.
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2019 Update of the American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.
Michael M. Ward,Atul Deodhar,Lianne S. Gensler,Maureen Dubreuil,David T. Y. Yu,Muhammad Asim Khan,Nigil Haroon,David G. Borenstein,Runsheng Wang,Ann Biehl,Meika A. Fang,Grant H. Louie,Vikas Majithia,Bernard Ng,Rosemary Bigham,Michael Pianin,Amit Aakash Shah,Nancy Sullivan,Marat Turgunbaev,Jeff Oristaglio,Amy S. Turner,Walter P. Maksymowych,Liron Caplan +22 more
TL;DR: To update evidence‐based recommendations for the treatment of patients with ankylosing spondylitis (AS) and nonradiographic axial spONDyloarthritis (SpA).
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Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study.
Désirée van der Heijde,Atul Deodhar,James Cheng-Chung Wei,E. Drescher,Dona Fleishaker,Thijs Hendrikx,David Li,Sujatha Menon,Keith S. Kanik +8 more
TL;DR: Tofacitinib 5 and 10 mg twice daily demonstrated greater clinical efficacy versus placebo in reducing signs, symptoms and objective endpoints of active AS in adult patients with a similar 12-week safety profile as reported in other indications.
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Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease.
TL;DR: This review will discuss reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and disease.
Journal ArticleDOI
Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis.
Francesco Ciccia,Giuliana Guggino,Aroldo Rizzo,Laura Saieva,S. Peralta,AnnaRita Giardina,Alessandra Cannizzaro,Guido Sireci,Giacomo De Leo,Riccardo Alessandro,Giovanni Triolo +10 more
TL;DR: Gut-derived IL-17+ and IL-22+ILC3 are expanded in the peripheral blood, SF and inflamed BM of patients with AS, suggesting the presence of an active homing axis between the gut and the inflamed sacroiliac joints.