G
Giacomo De Leo
Researcher at University of Palermo
Publications - 72
Citations - 4152
Giacomo De Leo is an academic researcher from University of Palermo. The author has contributed to research in topics: Microvesicles & Ciona intestinalis. The author has an hindex of 31, co-authored 72 publications receiving 3470 citations.
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Journal ArticleDOI
CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA
Alice Conigliaro,Viviana Costa,Alessia Lo Dico,Laura Saieva,Simona Buccheri,Francesco Dieli,Mauro Manno,Samuele Raccosta,Carmine Mancone,Marco Tripodi,Giacomo De Leo,Riccardo Alessandro,Riccardo Alessandro +12 more
TL;DR: A new exosome-mediated mechanism by which CSC-like CD90+ cells could influence their tumor microenvironment by promoting angiogenic phenotype and cell-to-cell adhesion is indicated.
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Exosomes as intercellular signaling organelles involved in health and disease: basic science and clinical applications.
Chiara Corrado,Stefania Raimondo,Antonio Chiesi,Francesco Ciccia,Giacomo De Leo,Riccardo Alessandro +5 more
TL;DR: This review will focus on exosomes as intercellular signaling organelles involved in a number of physiological as well as pathological processes and their potential use in clinical diagnostics and therapeutics.
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Exosomes released by K562 chronic myeloid leukemia cells promote angiogenesis in a src-dependent fashion
Marco Mineo,Marco Mineo,Susan H. Garfield,Simona Taverna,A. Flugy,Giacomo De Leo,Riccardo Alessandro,Elise C. Kohn +7 more
TL;DR: The inhibitory effect of dasatinib on exosome production and vascular differentiation and signaling reveals a key role for Src in both the leukemia and its microenvironment.
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Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo Chronic Myelogenous Leukemia cell growth.
Daniele Bellavia,Stefania Raimondo,Giovanna Calabrese,Stefano Forte,Marta Cristaldi,Agostina Patinella,Lorenzo Memeo,Mauro Manno,Samuele Raccosta,Patrizia Diana,Girolamo Cirrincione,Gianluca Giavaresi,Francesca Monteleone,Simona Fontana,Giacomo De Leo,Riccardo Alessandro +15 more
TL;DR: It is shown that IL3L exosomes, loaded with Imatinib or with BCR-ABL siRNA, are able to target CML cells and inhibit in vitro and in vivo cancer cell growth.
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Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death
Stefania Raimondo,Flores Naselli,Simona Fontana,Francesca Monteleone,Alessia Lo Dico,Laura Saieva,Giovanni Zito,A. Flugy,Mauro Manno,Maria Antonietta Di Bella,Giacomo De Leo,Riccardo Alessandro +11 more
TL;DR: This study identifies for the first time a fraction of vesicles from lemon juice obtained as a result of different ultracentrifugation, and shows that isolated nanovesicles inhibit cancer cell proliferation in different tumor cell lines, by activating a TRAIL-mediated apoptotic cell death.