Journal ArticleDOI
Topics in pharmacokinetics, III: Repeated dosage and impulse control
Reads0
Chats0
TLDR
Some novel types of control processes arising in the study of optimal drug administration are considered and are treated by dynamic programming techniques.Abstract:
Some novel types of control processes arising in the study of optimal drug administration are considered. These are treated by dynamic programming techniques.read more
Citations
More filters
Journal ArticleDOI
Input-to-state stability of impulsive and switching hybrid systems with time-delay
Jun Liu,Xinzhi Liu,Wei-Chau Xie +2 more
TL;DR: It is shown that, even if all the subsystems governing the continuous dynamics, in the absence of impulses, are not ISS/iISS, impulses can successfully stabilize the system in the ISS/ iISS sense, provided that there are no overly long intervals between impulses.
Journal ArticleDOI
Feedback control methods for drug dosage optimisation. Concepts, classification and clinical application.
S Vozeh,J L Steimer +1 more
TL;DR: A classification is proposed for dosage optimisation techniques which distinguishes between tight-loop and loose-loop methods depending on whether physician’s interaction is absent or included as part of the control step.
Journal ArticleDOI
Computer control systems and pharmacological drug administration: a survey
TL;DR: Clinical medicine, although basically a science apparently unrelated to control engineering, is being affected to such an extent that it is now possible to use available online control devices, especially during surgical operations and in intensive care units.
Journal ArticleDOI
Impulsive stabilization of stochastic functional differential equations
Jun Liu,Xinzhi Liu,Wei-Chau Xie +2 more
TL;DR: Both moment and almost sure exponential stability criteria are established using the Lyapunov–Razumikhin method and it is shown that an unstable stochastic delay system can be successfully stabilized by impulses.
Journal ArticleDOI
Microprocessor-based controller for pharmacodynamical applications
TL;DR: In this paper, an automatic drug delivery system for the purpose of keeping the output as close as possible to a desired value is presented, where the system input-output is first represented as an autoregressive model and a minimum variance controller is then designed to solve the control problem.