Total Synthesis of Theopederin D.

TLDR: In this article, the synthesis of the potent cytotoxin theopederin D has been achieved through the use of an oxidative carbon-carbon bond cleavage reaction to form an acyliminium ion in the presence of acid labile acetal groups.

Abstract: The total synthesis of the potent cytotoxin theopederin D has been achieved through the use of an oxidative carbon–carbon bond cleavage reaction to form an acyliminium ion in the presence of acid labile acetal groups Other key transformations include an acid mediated functionalization of a tetrahydrofuranyl alcohol in the presence of a tetrahydropyranyl alcohol, a syn-selective glycal epoxide opening, and a catalytic asymmetric aldehyde-acid chloride condensation.