Open AccessDissertation
Trypanotolerace in West African cattle and the population genetic effects of selection
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The article was published on 2002-01-01 and is currently open access. It has received 554 citations till now. The article focuses on the topics: Selection (genetic algorithm) & Population.read more
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Journal ArticleDOI
Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.
Eveline Snelders,Henrich A. L. van der Lee,Judith Kuijpers,Anthonius J. M. M. Rijs,János Varga,János Varga,Robert A. Samson,Emilia Mellado,A. Rogier T. Donders,Willem J. G. Melchers,Paul E. Verweij +10 more
TL;DR: The presence of a dominant resistance mechanism in clinical isolates suggests that isolates with this mechanism are spreading in the authors' environment, and might be more prevalent than currently acknowledged.
Journal ArticleDOI
Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles
Jan Willem van der Linden,Simone M. T. Camps,Greetje A. Kampinga,Jan P. Arends,Yvette J. Debets-Ossenkopp,Pieter Jan Haas,Bart J. A. Rijnders,Ed J. Kuijper,Frank H. van Tiel,János Varga,Anna Karawajczyk,G. Jan Zoll,Willem J. G. Melchers,Paul E. Verweij +13 more
TL;DR: Recovery of TR46/Y121F/T289A from the environment suggests an environmental route of resistance selection and describes the emergence and geographical migration of a voriconazole highly resistant A. fumigatus that was associated with vorIconazole treatment failure in patients with invasive aspergillosis.
Journal ArticleDOI
To what extent do microsatellite markers reflect genome-wide genetic diversity in natural populations?
TL;DR: The results imply that variability at microsatellite marker sets typically used in population studies may not accurately reflect the underlying genomic diversity, and researchers should consider using resequencing‐based approaches for assessing genetic diversity when accurate inference is critical, as in many conservation and management contexts.
Journal ArticleDOI
A first-generation microsatellite-based genetic linkage map of the Siberian jay (Perisoreus infaustus): insights into avian genome evolution
TL;DR: Apart from providing novel insights into sex-specific recombination rates and patterns, the described maps – from a previously genomically uncharacterized superfamily (Corvidae) of passerine birds – provide new insights into avian genome evolution.
Journal ArticleDOI
Transcript-specific, single-nucleotide polymorphism discovery and linkage analysis in hexaploid bread wheat Triticum aestivum L
Alexandra M. Allen,Gary L A Barker,Simon Berry,Jane A. Coghill,Rhian Gwilliam,Susan Kirby,Phil Robinson,Rachel Brenchley,Rosalinda D’Amore,Neil McKenzie,Darren Waite,Anthony Hall,Michael W. Bevan,Neil Hall,Keith J. Edwards +14 more
TL;DR: To mine selected elite wheat germplasm for intervarietal single-nucleotide polymorphisms, expressed sequence tags derived from public sequencing programmes and next-generation sequencing of normalized wheat complementary DNA libraries are used, in combination with a novel sequence alignment and assembly approach.
References
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Journal ArticleDOI
Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism.
Eveline Snelders,Henrich A. L. van der Lee,Judith Kuijpers,Anthonius J. M. M. Rijs,János Varga,János Varga,Robert A. Samson,Emilia Mellado,A. Rogier T. Donders,Willem J. G. Melchers,Paul E. Verweij +10 more
TL;DR: The presence of a dominant resistance mechanism in clinical isolates suggests that isolates with this mechanism are spreading in the authors' environment, and might be more prevalent than currently acknowledged.
Journal ArticleDOI
Aspergillosis due to Voriconazole Highly Resistant Aspergillus fumigatus and Recovery of Genetically Related Resistant Isolates From Domiciles
Jan Willem van der Linden,Simone M. T. Camps,Greetje A. Kampinga,Jan P. Arends,Yvette J. Debets-Ossenkopp,Pieter Jan Haas,Bart J. A. Rijnders,Ed J. Kuijper,Frank H. van Tiel,János Varga,Anna Karawajczyk,G. Jan Zoll,Willem J. G. Melchers,Paul E. Verweij +13 more
TL;DR: Recovery of TR46/Y121F/T289A from the environment suggests an environmental route of resistance selection and describes the emergence and geographical migration of a voriconazole highly resistant A. fumigatus that was associated with vorIconazole treatment failure in patients with invasive aspergillosis.
Journal ArticleDOI
To what extent do microsatellite markers reflect genome-wide genetic diversity in natural populations?
TL;DR: The results imply that variability at microsatellite marker sets typically used in population studies may not accurately reflect the underlying genomic diversity, and researchers should consider using resequencing‐based approaches for assessing genetic diversity when accurate inference is critical, as in many conservation and management contexts.
Journal ArticleDOI
A first-generation microsatellite-based genetic linkage map of the Siberian jay (Perisoreus infaustus): insights into avian genome evolution
TL;DR: Apart from providing novel insights into sex-specific recombination rates and patterns, the described maps – from a previously genomically uncharacterized superfamily (Corvidae) of passerine birds – provide new insights into avian genome evolution.
Journal ArticleDOI
Transcript-specific, single-nucleotide polymorphism discovery and linkage analysis in hexaploid bread wheat Triticum aestivum L
Alexandra M. Allen,Gary L A Barker,Simon Berry,Jane A. Coghill,Rhian Gwilliam,Susan Kirby,Phil Robinson,Rachel Brenchley,Rosalinda D’Amore,Neil McKenzie,Darren Waite,Anthony Hall,Michael W. Bevan,Neil Hall,Keith J. Edwards +14 more
TL;DR: To mine selected elite wheat germplasm for intervarietal single-nucleotide polymorphisms, expressed sequence tags derived from public sequencing programmes and next-generation sequencing of normalized wheat complementary DNA libraries are used, in combination with a novel sequence alignment and assembly approach.