Journal ArticleDOI
Unusual bone marrow manifestations of parvovirus B19 infection in immunocompromised patients.
Terri W. Crook,Beverly Barton Rogers,Richard D. McFarland,Steven H. Kroft,Pietro Muretto,Jose A. Hernandez,M. Jane Latimer,Robert W. McKenna +7 more
TLDR
The findings of erythroid maturation and abundant viral inclusions in these immunocompromised patients is consistent with the hypothesis that failure to produce effective IgG parvovirus neutralizing antibodies may lead to persistent infection through viral tolerance that allows erythyroid development of infected cells past the pronormoblast stage.About:
This article is published in Human Pathology.The article was published on 2000-02-01. It has received 28 citations till now. The article focuses on the topics: Parvovirus infection & Parvovirus.read more
Citations
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Journal ArticleDOI
Human Parvovirus B19
Erik D. Heegaard,Kevin E. Brown +1 more
TL;DR: Parvovirus B19 was discovered in 1974 and is the only member of the family Parvoviridae known to be pathogenic in humans, anddiagnosis is primarily based on detection of specific antibodies by enzyme-linked immunosorbent assay or detection of viral DNA by dot blot hybridization or PCR.
Journal ArticleDOI
Parvovirus B19 in pregnancy.
Zivanit Ergaz,Asher Ornoy +1 more
TL;DR: Since Parvovirus B19 infection should be part of the routine work up of complicated pregnancies, risk assessment for maternal infection during pregnancy is especially important during epidemics when sero-conversion rates are high.
Journal ArticleDOI
Parvovirus-B19-associated complications in renal transplant recipients
Meryl Waldman,Jeffrey B. Kopp +1 more
TL;DR: The most common manifestations of B19 infection in immunosuppressed patients are pure red cell aplasia and other cytopenias, and this diagnosis should be considered in transplant recipients with unexplained anemia and reticulocytopenia or pancy topenia.
Journal ArticleDOI
Fifth (human parvovirus) and sixth (herpesvirus 6) diseases.
TL;DR: The relationship between the viruses and these conditions remains controversial, and better diagnostic tests and further information on viral pathogenesis for both viruses are required in order to make a reliable judgment in this regard.
Journal ArticleDOI
Direct Ex Vivo Measurement of CD8+T-Lymphocyte Responses to Human Parvovirus B19
Thomas Tolfvenstam,Annette Oxenius,David Price,Barbara L. Shacklett,Hans M. L. Spiegel,Klaus Hedman,Oscar Norbeck,Michael Levi,K. Olsen,Maria Kantzanou,Douglas F. Nixon,Kristina Broliden,Paul Klenerman +12 more
TL;DR: The mapping of the first parvovirus B19-derived CD8+ T-lymphocyte epitope is described, which derives from the nonstructural (NS1) protein and is strongly immunogenic in B19 virus-seropositive donors.
References
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Parvovirus infections and hypoplastic crisis in sickle-cell anaemia
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Persistent B19 parvovirus infection in patients infected with human immunodeficiency virus type 1 (HIV-1): a treatable cause of anemia in AIDS.
Norbert Frickhofen,Janis L. Abkowitz,Monika M. Safford,J. Michael Berry,Jorge Antunez-de-Mayolo,Alan B. Astrow,Robert Cohen,Ira Halperin,Lambert N. King,David M. Mintzer,Bernard J. Cohen,Neal S. Young +11 more
TL;DR: The B19 parvovirus is a remediable cause of severe chronic anemia in HIV-infected patients and recognition of and therapy for parVovirus in this population will avoid erythrocyte transfusion and should prevent transmission of the virus to other persons, including immunosuppressed persons and women of child-bearing age.
Journal ArticleDOI
Chronic bone marrow failure due to persistent B19 parvovirus infection.
TL;DR: The B19 parvovirus, which was serendipitously discovered in serum from blood-bank donors in 1975, has been associated with several human illnesses and is the etiologic agent of the common childhood exanthem called fifth disease.
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Pure red-cell aplasia of 10 years' duration due to persistent parvovirus B19 infection and its cure with immunoglobulin therapy.
Gary J. Kurtzman,Norbert Frickhofen,Janice Kimball,Douglas W. Jenkins,Arthur W. Nienhuis,Neal S. Young +5 more
TL;DR: In tissue-culture studies, parvovirus B19 is the etiologic agent of transient aplastic crisis, an acute episode of bone marrow failure in persons with underlying hemolysis.
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Human parvovirus infection in pregnancy and hydrops fetalis.
TL;DR: It is concluded that this common virus may pose a serious risk to the fetus after maternal infection in women with serologic evidence of having contracted human parvovirus infection during pregnancy.