Journal ArticleDOI
Unusual conversion of substituted-3-formylchromones to 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones: a facile and efficient route to novel 1,2,4-dithiazoles
Tilak Raj,Mohan Paul S. Ishar,Vivek K. Gupta,Ajay Pal Singh Pannu,Priyanka Kanwal,Gurpinder Singh +5 more
TLDR
Substituted 3-formylchromones react with 2-phenyl-4-dimethylamino-1-thia-3-azabuta-1,3-diene ( 4 ) or thio-benzamide ( 7 ) by heating their toluene solution in a sealed tube to give novel substituted 3-(5phenyl)-3 H -[1,2,4]dithiazol-3yl)chromen-4ones ( 6a − e ) in high yields as discussed by the authors.About:
This article is published in Tetrahedron Letters.The article was published on 2008-01-07. It has received 23 citations till now.read more
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Catalytic Non-Enzymatic Kinetic Resolution
TL;DR: Corey et al. as discussed by the authors provided an update on the principal developments of catalytic non-enzymatic kinetic resolution (KR) covering the literature since 2004, which is the most important industrial approach to the synthesis of chiral compounds.
Journal ArticleDOI
Cytotoxic activity of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides.
Tilak Raj,Richa Kaur Bhatia,Ashish Kapur,Madhunika Sharma,Ajit Kumar Saxena,Mohan Paul S. Ishar +5 more
TL;DR: 6/6,7-Substituted-3-formylchromones (8a-g) were reacted with 2 equivalents thiobenzamide in refluxing toluene to furnish substituted-3-(5-phenyl-3H-[1,2,4]dithiazol- 3-yl)chromen-4-ones (10a-G) in high yields.
Journal ArticleDOI
Recyclizations of 3-formylchromones with binucleophiles
Andrey S. Plaskon,Andrey S. Plaskon,Oleksandr O. Grygorenko,Oleksandr O. Grygorenko,Sergey V. Ryabukhin +4 more
Journal ArticleDOI
Mechanism of unusual formation of 3-(5-phenyl-3H-[1,2,4]dithiazol-3-yl)chromen-4-ones and 4-oxo-4H-chromene-3-carbothioic acid N-phenylamides and their antimicrobial evaluation.
Tilak Raj,Richa Kaur Bhatia,Rakesh Kumar Sharma,Vivek K. Gupta,Deepak Sharma,Mohan Paul S. Ishar +5 more
TL;DR: Dithiazole 12d exhibits a very high antifungal activity better than fluconazole (MIC 09 microg/ml) and also possesses good antibacterial activity against Shigella flexneri.
Journal ArticleDOI
An update on the stereoselective synthesis of γ-amino acids
TL;DR: In this article, the most recent papers describing the stereoselective synthesis of γ-amino acids have been classified according to the type of compounds, position and number of substituents.
References
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TL;DR: Important molecules discussed include Vincristine, Vinblastine, Colchicine, Ellipticine and Lepachol along with Flavopiridol, a semi-synthetic analogue of the chromone alkaloid Rohitukine from India, a pyridoindole alkaloids from leaves of Ochrosia species and many more.
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Natural products as a source of potential cancer chemotherapeutic and chemopreventive agents.
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Cytotoxic flavonoids with isoprenoid groups from Morus mongolica
Ya-Qin Shi,Toshio Fukai,Hiroshi Sakagami,Wen-Jin Chang,Pei-Quan Yang,Feng-Peng Wang,Taro Nomura +6 more
TL;DR: All flavanones investigated here showed higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF) and the cytot toxicity of compound 2 and the Diels-Alder type flavanone sanggenon C isolated from Morus cathayana were the most potent.
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Secondary DNA structures as molecular targets for cancer therapeutics.
TL;DR: The design and synthesis of small molecules that target these secondary DNA struc- tures and the biochemical and biological effects of these compounds are of potential importance in cancer chemotherapy.