Journal ArticleDOI
Validation of an indirect calorimeter to measure oxygen consumption in critically ill patients
Juan J. Ronco,P. Terry Phang +1 more
TLDR
In this paper, a system of indirect calorimetry (Deltatrac Metabolic Monitor) was used to measure oxygen consumption and sensitivity to detect small changes in oxygen consumption, in vitro, using a lung model simulation of ventilating patients who have stiff lungs.About:
This article is published in Journal of Critical Care.The article was published on 1991-03-01. It has received 48 citations till now.read more
Citations
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Journal ArticleDOI
Effect of Stored-Blood Transfusion on Oxygen Delivery in Patients With Sepsis
Paul E. Marik,William J. Sibbald +1 more
TL;DR: It is postulate that the poorly deformable transfused red blood cells cause micro-circulatory occlusion in some organs, which may lead to tissue ischemia inSome organs.
Journal ArticleDOI
The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis
Paul E. Marik,Mohammed Mohedin +1 more
TL;DR: It is suggested that dopamine may cause an uncompensated increase in splanchnic oxygen requirements in septic patients and Norepinephrine, however, may have a more favorable hemodynamic profile and improve splan Schnic tissue oxygen utilization in sepsis.
Journal ArticleDOI
Identification of the Critical Oxygen Delivery for Anaerobic Metabolism in Critically III Septic and Nonseptic Humans
Juan J. Ronco,John C. Fenwick,Martin Tweeddale,Barry Wiggs,Phang Pt,D. J. Cooper,K F Cunningham,James A. Russell,Keith R. Walley +8 more
TL;DR: The critical oxygen delivery threshold for anaerobic metabolism was identified from the biphasic relationship between O2 delivery and O2 consumption in individual humans and is considerably lower than previously reported in humans with the use of pooled group data.
Journal ArticleDOI
Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients.
Constantino José Fernandes,Nelson Akamine,Fernando Vinicius Cesar De Marco,José Am De Souza,Sofia Lagudis,Elias Knobel +5 more
TL;DR: Hemoglobin increase does not improve either global or regional oxygen utilization in anemic septic patients, and RBC transfusion may hamper right ventricular ejection by increasing the pulmonary vascular resistance index.
Journal ArticleDOI
Oxygen Consumption Is Independent of Increases in Oxygen Delivery by Dobutamine in Septic Patients Who Have Normal or Increased Plasma Lactate
TL;DR: Whether the relationship between oxygen delivery and oxygen consumption is different between patients who have sepsis and normal (n = 6) or increased ( n = 8) concentrations of plasma lactate is asked and determined oxygen consumption using analysis of respiratory gases while increasing oxygen delivery using a dobutamine infusion.
References
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Journal ArticleDOI
An Expanded Definition of the Adult Respiratory Distress Syndrome
TL;DR: An expanded definition of ARDS is proposed that takes into account new knowledge about adult respiratory distress syndrome and its clinical features, physiologic disturbances, prognosis, and pathologic findings.
Journal ArticleDOI
A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock.
Roger C. Bone,Charles J. Fisher,Terry P. Clemmer,Gus J. Slotman,Craig A. Metz,Robert A. Balk +5 more
TL;DR: It is concluded that the use of high-dose corticosteroids provides no benefit in the treatment of severe sepsis and septic shock.
Journal ArticleDOI
The Effects of Vasodilation with Prostacyclin on Oxygen Delivery and Uptake in Critically Ill Patients
TL;DR: Data suggest the presence of a substantial oxygen debt in patients who subsequently die, which appears to be an important mechanism contributing to the development of irreversible multiple organ failure and subsequent death in some patients with acute respiratory failure.
Journal ArticleDOI
The concept of a critical oxygen delivery.
Paul T. Schumacker,S. M. Cain +1 more
TL;DR: To the extent this abnormal dependence of VO2 on QO2 reflects tissue hypoxia, clinical interventions which decrease systemic delivery should be evaluated with regard to possible deleterious effects on organ system function.
Journal ArticleDOI
Mathematic coupling of data: a common source of error.
TL;DR: Four types of mathematic coupling of data are identified: direct algebraic coupling between two variables, when one or more of the variables is derived and/or calculated, and indirect coupling or physiologic coupling, which involves directional changes in two variables which are mathematically coupled.