Open AccessJournal Article
Vascular endothelial growth factor gene polymorphisms and gastric cancer risk: a meta-analysis.
TLDR
A meta-analysis suggests that VEGF-634 G allele carrier may increase gastric cancer risk, whereas the V EGF +1612 G/A G allele and G allele carriers may decrease the risk.Abstract:
PURPOSE Vascular endothelial growth factor (VEGF) plays important roles in the process of tumor growth and metastasis. Although the association between VEGF polymorphisms and gastric cancer risk has been extensively studied, available results remain controversial. To derive a convincing estimation of the relationship, a meta-analysis containing 6 VEGF (+936C/T, -634G/C, -460T/C, +1612G/A, -2578C/A and -1154G/A) gene polymorphisms was performed. METHODS We conducted a systematic search of PubMed and Chinese National Knowledge Infrastructure (CNKI) to select relevant articles. Nine available case-control studies with 2,281 gastric cancer cases and 2,820 healthy controls met the inclusion criteria. The odds ratio (OR) and 95% confidence interval (95% CI) were used to evaluate the strength of the association. RESULTS This meta-analysis indicated that the VEGF-634 G allele carrier represented a risk factor for gastric cancer (GG+GC vs CC: OR=1.23, 95% CI=1.02-1.49, p=0.03). The VEGF +1612G/A polymorphism was associated with risk of gastric cancer (G allele vs A allele: OR=0.62, 95% CI=0.49- 0.79, p<0.0001; GG+GA vs AA: OR=0.16, 95% CI=0.05-0.51, p=0.002 and GA+AA vs GG: OR=1.57, 95% CI=1.21-2.04, p=0.008). For polymorphisms of VEGF +936C/T, -460C/T, -2578C/A , -1154G/A, no association was found with gastric cancer risk. CONCLUSION Our meta-analysis suggests that VEGF-634 G allele carrier may increase gastric cancer risk, whereas the VEGF +1612 G/A G allele and G allele carrier may decrease the risk. No association between+936C/T, -460C/T, -2578C/A, -1154G/A polymorphisms and susceptibility to gastric cancer was found.read more
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Transferrin receptor-1 and VEGF are prognostic factors for osteosarcoma.
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Genetic polymorphisms of vascular endothelial growth factor (VEGF) associated with gastric cancer recurrence after curative resection with adjuvant chemotherapy
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H3K27me3 and VEGF is associated with poor prognosis in patients with synovial sarcoma.
TL;DR: H3K 27me3 and VEGF expression are both significantly associated with overall survival of synovial sarcoma, and H3K27me3 is a significant independent prognostic indicator in patients with synovials.
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Journal Article
Haplotype Analysis of the Polymorphic Human Vascular Endothelial Growth Factor Gene Promoter
TL;DR: Carriage of the -460/+405 polymorphism significantly alters VEGF promoter activity and responsiveness, which has implications for the inherited susceptibility of common diseases.