N
Nicholas J. A. Webb
Researcher at Boston Children's Hospital
Publications - 124
Citations - 5162
Nicholas J. A. Webb is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Transplantation & Kidney disease. The author has an hindex of 30, co-authored 119 publications receiving 4286 citations. Previous affiliations of Nicholas J. A. Webb include National Institute for Health Research & Manchester Royal Infirmary.
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Journal ArticleDOI
2016 European Society of Hypertension guidelines for the management of high blood pressure in children and adolescents
Empar Lurbe,Enrico Agabiti-Rosei,J. Kennedy Cruickshank,Anna F. Dominiczak,Serap Erdine,Asle Hirth,Cecilia Invitti,Mieczysław Litwin,Giuseppe Mancia,Dénes Páll,Wolfgang Rascher,Josep Redon,Franz Schaefer,Tomáš Seeman,Manish D. Sinha,Stella Stabouli,Nicholas J. A. Webb,Elke Wühl,Alberto Zanchetti +18 more
TL;DR: The recommendations of the present document represent the best clinical wisdom upon which physicians, nurses and families should base their decisions and should encourage public policy makers to develop a global effort to improve identification and treatment of high blood pressure among children and adolescents.
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Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production.
TL;DR: A significant correlation was observed between lipopolysaccharide stimulated peripheral blood mononuclear cell (PBMC) VEGF protein production and genotype for the +405 polymorphism and a combined sequence specific priming (SSP) PCR typing system to determine the cis/trans orientation of each allele and hence, ascertain haplotypes.
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Vascular endothelial growth factor (VEGF) is released from platelets during blood clotting: implications for measurement of circulating VEGF levels in clinical disease
TL;DR: The data suggest that plasma is the preferred medium to measure VEGF levels; a significant and highly variable platelet-mediated secretion of V EGF during the clotting process invalidates the use of serum as an indicator of circulating VEGf levels in disease states.
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Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management
Agnieszka Bierzynska,Hugh J. McCarthy,Katrina Soderquest,Ethan S Sen,Elizabeth Colby,Wen Y. Ding,Marwa M. Nabhan,Larissa Kerecuk,Shivram Hegde,David Hughes,Stephen D. Marks,Sally Feather,Caroline Jones,Nicholas J. A. Webb,Milos Ognjanovic,Martin Christian,Rodney D. Gilbert,Manish D. Sinha,Graham M. Lord,Michael A. Simpson,Ania Koziell,Gavin I. Welsh,Moin A. Saleem +22 more
TL;DR: Deep phenotyping combined with whole exome sequencing is an effective tool for early identification of SRNS etiology, yielding an evidence-based algorithm for clinical management.
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Rare hereditary COL4A3/COL4A4 variants may be mistaken for familial focal segmental glomerulosclerosis.
Andrew F. Malone,Andrew F. Malone,Paul J. Phelan,Paul J. Phelan,Gentzon Hall,Gentzon Hall,Umran Cetincelik,Alison Homstad,Alison Homstad,Andrea S. Alonso,Andrea S. Alonso,Ruiji Jiang,Ruiji Jiang,Thomas Lindsey,Guanghong Wu,Matthew A. Sparks,Stephen R. Smith,Nicholas J. A. Webb,Philip A. Kalra,Adebowale Adeyemo,Andrey S. Shaw,Peter J. Conlon,J. Charles Jennette,David N. Howell,Michelle P. Winn,Michelle P. Winn,Rasheed Gbadegesin,Rasheed Gbadegesin +27 more
TL;DR: This study illustrates the power of molecular genetic diagnostics in the clarification of renal phenotypes by presenting seven families with rare or novel variants in COL4A3 orCOL4A4 from a cohort of 70 families with a diagnosis of hereditary FSGS.