Journal ArticleDOI
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Eric B. Rimm,Meir J. Stampfer,Alberto Ascherio,Edward Giovannucci,Graham A. Colditz,Walter C. Willett +5 more
TLDR
Evidence is provided of an association between a high intake of vitamin E and a lower risk of coronary heart disease in men, and public policy recommendations with regard to the use ofitamin E supplements should await the results of additional studies.Abstract:
Background The oxidative modification of low-density lipoproteins increases their incorporation into the arterial intima, an essential step in atherogenesis. Although dietary antioxidants, such as vitamin C, carotene, and vitamin E, have been hypothesized to prevent coronary heart disease, prospective epidemiologic data are sparse. Methods In 1986, 39,910 U.S. male health professionals 40 to 75 years of age who were free of diagnosed coronary heart disease, diabetes, and hypercholesterolemia completed detailed dietary questionnaires that assessed their usual intake of vitamin C, carotene, and vitamin E in addition to other nutrients. During four years of follow-up, we documented 667 cases of coronary disease. Results After controlling for age and several coronary risk factors, we observed a lower risk of coronary disease among men with higher intakes of vitamin E (P for trend = 0.003). For men consuming more than 60 IU per day of vitamin E, the multivariate relative risk was 0.64 (95 percent confidence in...read more
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Journal ArticleDOI
Atherosclerosis — An Inflammatory Disease
TL;DR: Atherosclerosis is an inflammatory disease as discussed by the authors, and it is a major cause of death in the United States, Europe, and much of Asia, despite changes in lifestyle and use of new pharmacologic approaches to lower plasma cholesterol concentrations.
Journal Article
Atherosclerosis is an Inflammatory Disease
光宏 横山,Russell Ross +1 more
TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
Journal ArticleDOI
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Requirement for Generation of H2O2 for Platelet-Derived Growth Factor Signal Transduction
TL;DR: The results suggest that H2O2 may act as a signal-transducing molecule, and they suggest a potential mechanism for the cardioprotective effects of antioxidants.
Journal ArticleDOI
Role of Oxidative Modifications in Atherosclerosis
Roland Stocker,John F. Keaney +1 more
TL;DR: An "oxidative response to inflammation" model is proposed as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.
References
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Journal ArticleDOI
Oxidative stress: oxidants and antioxidants
TL;DR: These low molecular mass antioxidant molecules add significantly to the defense provided by the enzymes superoxide dismutase, catalase and glutathione peroxidases, which are termed ‘oxidative stress’.
Journal ArticleDOI
Reproducibility and validity of a semiquantitative food frequency questionnaire
Walter C. Willett,Walter C. Willett,Laura Sampson,Meir J. Stampfer,Meir J. Stampfer,Bernard Rosner,Chris Bain,Jelia C. Witschi,Charles H. Hennekens,Frank E. Speizer +9 more
TL;DR: Data indicate that a simple self-administered dietary questionnaire can provide useful information about individual nutrient intakes over a one-year period.
Journal ArticleDOI
Total energy intake: implications for epidemiologic analyses
TL;DR: While pitfalls in the manipulation and interpretation of energy intake data in epidemiologic studies have been emphasized, these considerations also highlight the usefulness of obtaining a measurement of total caloric intake, which is not accomplished with nutrient density measures of dietary intake.
Journal ArticleDOI
Chi-Square Tests with One Degree of Freedom; Extensions of the Mantel-Haenszel Procedure
TL;DR: In this article, a method for analyzing multiple 2×2 contingency tables arising in retrospective studies of disease is extended in application and form, which includes comparisons of age-adjusted death rates, life-table analyses, comparisons of two sets of quantal dosage response data, and miscellaneous laboratory applications as appropriate.
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