What are the long-term symptoms and complications of COVID-19: a protocol for a living systematic review
Melina Michelen,Louise Sigfrid,Lakshmi Manoharan,Natalie Elkheir,Natalie Elkheir,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Vincent Cheng,Amanda Burls,Carol Foote,Charitini Stavropoulou +11 more
TLDR
A protocol for a living systematic review that aims to synthesize the evidence on the prevalence and duration of symptoms and clinical features of post-acute CO VID-19 and its long-term complications to support the work of policy makers, practitioners, and patients when planning rehabilitation for those recovering from COVID-19.Abstract:
Although the majority of people with Covid-19 will experience mild to moderate symptoms and will recover fully, there is now increasing evidence that a significant proportion will experience persistent symptoms for months after the acute phase of the illness. These symptoms include, among others, fatigue, problems breathing, lack of smell and taste, headaches, and depression and anxiety. It is also clear the virus has lasting fluctuating multiorgan sequelae, including affecting not only the respiratory system but also the heart, liver, and nervous system. We present a protocol for a living systematic review that aims to synthesize the evidence on the prevalence and characteristics of post-acute COVID-19. The living systematic review will be updated regularly, approximately every 6 months, as new evidence emerges. We will include studies that follow up at least 100 people with Covid-19 at 12 or more weeks post Covid-19 onset, with no restrictions regarding country, setting, or language. We will use descriptive statistics and, for outcomes reported in two or more studies, we will use meta-analyses to estimate prevalence with 95% confidence intervals (CIs) using the exact method. Heterogeneity between estimates will be assessed using the I2 statistic. Our findings will also be presented as infographics to facilitate transcription to lay audiences. Ultimately, we aim to support the work of policy makers, practitioners, and patients when planning rehabilitation for those recovering from Covid-19. The protocol has been registered with PROSPERO ( CRD42020211131, 25/09/2020).read more
Citations
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Journal ArticleDOI
Characterising long COVID: a living systematic review.
Melina Michelen,Melina Michelen,Lakshmi Manoharan,Natalie Elkheir,Vincent Cheng,Andrew Dagens,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Dania T Dahmash,Polina Bugaeva,Ishmeala Rigby,Daniel Munblit,Daniel Munblit,Eli Harriss,Amanda Burls,Carole Foote,Janet T Scott,Gail Carson,Piero Olliaro,Louise Sigfrid,Charitini Stavropoulou +21 more
TL;DR: In this article, a living systematic review was conducted to synthesize evidence on Long Covid characteristics, to inform clinical management, rehabilitation, and interventional studies to improve long term outcomes.
Posted ContentDOI
Characterising long-term covid-19: a rapid living systematic review
Melina Michelen,Melina Michelen,Vincent Cheng,Lakshmi Manoharan,Natalie Elkheir,Natalie Elkheir,Drew Dagens,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Dania T Dahmash,Polina Bugaeva,Ishmeala Rigby,Daniel Munblit,Daniel Munblit,Eli Harriss,Amanda Burls,Carol Foote,Janet T Scott,Gail Carson,Piero Olliaro,Louise Sigfrid,Charitini Stavropoulou +22 more
TL;DR: The findings suggest that long covid is a complex, heterogeneous condition; however, the limited evidence base currently precludes a precise definition of its symptoms and prevalence.
Journal ArticleDOI
Enhancing the management of long COVID in general practice: a scoping review
TL;DR: In this article , the authors identified key concepts and knowledge gaps around long COVID by conducting a scoping review of literature on the condition's management by GPs, and six themes were identified regarding GP management of Long COVID, these being: (1) GP uncertainty, (2) listening and empathy, (3) assessment and monitoring of symptoms, (4) coordinating access to appropriate services, (5) facilitating provision of continual and integrated multidisciplinary care and (6) need to provide or facilitate psychological support.
Journal ArticleDOI
Enhancing the management of long COVID in general practice: a scoping review
Aimee Brennan,John Broughan,Geoff McCombe,John Brennan,Claire Collins,Ronan Fawsitt,Joe Gallagher,Allys Guerandel,Brendan O'Kelly,Diarmuid Quinlan,John S. Lambert,Walter Cullen +11 more
TL;DR: The findings show that GPs can and have played a key role in the management of Long COVID, and that patient care can be improved through better understanding of patient experiences, standardised approaches for symptom identification/treatment, and facilitation of access to multidisciplinary specialist services when needed.
Posted ContentDOI
Characterising Long Covid: a living systematic review update with controlled studies
Melina Michelen,Louise Sigfrid,Christiana Kartsonaki,Ian Shemilt,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Elisabeth A Stelson,Polina Bugaeva,Dania T Dahmash,Ishmeala Rigby,Daniel Munblit,Eli Harriss,Amanda Burls,Vincent Cheng,Jacqui Scott,Gail Carson,Piero Olliaro,Chrysa Stavropoulou +18 more
TL;DR: SARS-CoV-2 infection is associated with a higher risk of new or persistent symptoms when compared with controls that can last over a year following acute Covid-19, and future research should explore the role of vaccination and different variants on the risk of developing Long Covid.
References
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Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
David Moher,Larissa Shamseer,Mike Clarke,Davina Ghersi,Alessandro Liberati,Mark Petticrew,Paul G. Shekelle,Lesley A. Stewart +7 more
TL;DR: A reporting guideline is described, the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Protocols 2015 (PRISMA-P 2015), which consists of a 17-item checklist intended to facilitate the preparation and reporting of a robust protocol for the systematic review.
Ítems de referencia para publicar Protocolos de Revisiones Sistemáticas y Metaanálisis: Declaración PRISMA-P 2015 Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement
David Moher,Larissa Shamseer,Michael Clarke,Davina Ghersi,Alessandro Liberati,Mark Petticrew,Lesley A. Stewart +6 more
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Rayyan-a web and mobile app for systematic reviews.
TL;DR: The strongest features of the app, identified and reported in user feedback, were its ability to help in screening and collaboration as well as the time savings it affords to users.
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Persistent Symptoms in Patients After Acute COVID-19.
TL;DR: This case series describes COVID-19 symptoms persisting a mean of 60 days after onset among Italian patients previously discharged from CO VID-19 hospitalization.
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