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Open AccessJournal ArticleDOI

"White coat" versus "sustained" borderline hypertension in Tecumseh, Michigan.

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TLDR
Findings do not support the accepted practice of using home blood pressure determination to distinguish groups of borderline hypertensive subjects with a lesser or greater clinical problem.
Abstract
During a survey of young subjects not receiving treatment for hypertension in Tecumseh, Michigan, clinic and self-monitored blood pressures taken at home (14 readings in 7 days) were obtained in 737 subjects (387 men, 350 women, average age 31.5 years). Hypertension in the clinic was diagnosed if the clinic blood pressure exceeded 140 mm Hg systolic or 90 mm Hg diastolic. In the absence of firm criteria for what constitutes hypertension at home, subjects whose average home blood pressure was in the upper decile of the whole population were considered to have hypertension at home. By these criteria, 7.1% of the whole population had "white coat" hypertension (i.e., high clinic but not elevated home readings). The prevalence of "sustained" hypertension (i.e., high readings in the clinic and at home) was 5.1%. Subjects with white coat and sustained borderline hypertension in Tecumseh were very similar. Both groups showed, at previous examinations (at ages 5, 8, 21, and 23 years), significantly higher blood pressure readings than the normotensive subjects. As young adults (average age 33.3 years), the parents of both hypertensive groups had significantly higher blood pressure readings than the parents of normotensive subjects. Both hypertensive groups had faster heart rates, higher systemic vascular resistance, and higher minimal forearm vascular resistance. Both hypertensive groups were more overweight, had higher plasma triglycerides, insulin, and insulin/glucose ratios than normotensive subjects. The white coat hypertensive group also had lower values of high density lipoprotein than the normotensive group. White coat hypertension is a frequent condition.(ABSTRACT TRUNCATED AT 250 WORDS)

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Citations
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Journal ArticleDOI

Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension.

TL;DR: It is suggested that ambulatory blood pressures stratifies cardiovascular risk in essential hypertension independent of clinic blood pressure and other traditional risk markers including echocardiographic left ventricular hypertrophy.
Journal ArticleDOI

Ambulatory Blood Pressure Is Superior to Clinic Blood Pressure in Predicting Treatment-Induced Regression of Left Ventricular Hypertrophy

TL;DR: This data indicates that ambulatory blood pressure correlates more closely than clinic BP with the organ damage of hypertension and whether ABP predicts development or regression of hypertension-related morbidity and mortality is still under investigation.
Book ChapterDOI

Endothelial Dysfunction and Hypertension.

TL;DR: The aim of this chapter is to explain endothelial dysfunction and the circulating molecules of endothelial cells as they become potential targets of therapeutic approach for hypertension, and the role of endothelium dysfunction in white coat hypertension has been discussed.
Journal ArticleDOI

Psychological stress and the progression of carotid artery disease.

TL;DR: The hypothesis that hemodynamic responses under conditions of mental stress may influence the progression of atherosclerosis is supported.
References
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Journal ArticleDOI

Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hypertension.

TL;DR: The findings demonstrate that the severity of hypertension is more closely related to 24-h mean BP than to cuff BP values, and confirmed that 24-H BP may be variably different from cuff BP among subjects.
Journal ArticleDOI

The prognostic value of ambulatory blood pressures.

TL;DR: It is concluded that ABP was an important determinant of clinical outcome among patients with essential hypertension whose condition had been initially evaluated with both ambulatory BP (ABP) and office BP measurements.
Journal ArticleDOI

Left ventricular hypertrophy in patients with hypertension: importance of blood pressure response to regularly recurring stress.

TL;DR: It is concluded that hypertensive LVH is poorly related to clinical or home measurements of blood pressure but that a substantially closer relationship exists betweenLVH and blood pressure during recurring stress at work and between LVH and home blood pressure on a workday.
Journal ArticleDOI

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

TL;DR: Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response, and this response was inhibited by the nonselective alpha adrenergic antagonist phentolamine and by the alpha 2 adrenergic antagonists prazosin and terazosin.
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