Q1. What are the contributions in "Who-eortc classification for cutaneous lymphomas" ?
Willemze et al. this paper presented the new WHO-EORTC classification for cutaneous lymphomas.
WHO-EORTC classification for cutaneous lymphomas.
Rein Willemze,Elaine S. Jaffe,Günter Burg,Lorenzo Cerroni,Emilio Berti,Steven H. Swerdlow,Elisabeth Ralfkiaer,Sergio Chimenti,José Luis Diaz-Perez,Lyn M. Duncan,Florent Grange,Nancy L. Harris,Werner Kempf,Helmut Kerl,Michael O. Kurrer,Robert Knobler,Nicola Pimpinelli,Chris Sander,Marco Santucci,Wolfram Sterry,Maarten H. Vermeer,Janine Wechsler,Sean Whittaker,Chris J.L.M. Meijer +23 more
TLDR
The characteristic features of the different primary cutaneous lymphomas and other hematologic neoplasms frequently presenting in the skin are described, and differences with the previous classification schemes are discussed.About:
This article is published in Blood.The article was published on 2005-05-15 and is currently open access. It has received 3530 citations till now. The article focuses on the topics: Primary cutaneous marginal zone lymphoma & Cutaneous B-cell lymphoma.read more
Figures
Figure 8. Primary cutaneous marginal zone lymphoma. Characteristic clinical presentation with multiple nodules and small tumors on the back and arms. 
Figure 7. CD4 /CD56 hematodermic neoplasm (blastic NK-cell lymphoma). (A) Presentation with large tumor on the back. (B) Monotonous infiltration of mediumsized tumor cells (H&E staining; original magnification, 480). (C) The tumor cells strongly express CD56. Image acquisition for panels B and C was performed as described for Figure 1B. An HC Plan APO 40 /0.85 objective lens was used. 
Table 1. WHO-EORTC classification of cutaneous lymphomas with primary cutaneous manifestations 
Table 2. Relative frequency and disease-specific 5-year survival of 1905 primary cutaneous lymphomas classified according to the WHO-EORTC classification 
Figure 3. Primary cutaneous CD30 lymphoproliferative disease (pcCD30 LPD). (A) Diffuse dermal infiltrate of large atypical cells admixed with small lymphocytes. (H&E staining; original magnification, 300). (B) The large atypical cells are strongly positive for CD30. (C-D) The histologic picture in panels A and B can be found both in C-ALC and in LyP. The final diagnosis depends on the clinical presentation. In combination with the solitary tumor of the patient shown in panel C the definite diagnosis will be C-ALC; in combination with recurrent, self-healing papulonecrotic skin lesions (D), the final diagnosis is LyP. Image acquisition for panels A and B was performed as described for Figure 1B. An HC Plan APO 20 /0.70 objective was used. 
Figure 6. Primary cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma. (A) Presentation with a solitary tumor on the scalp. (B) Diffuse dermal infiltrate mainly composed of small pleomorphic T cells with few scattered blasts cells (H&E staining; original magnification, 750). Image acquisition was performed as described for Figure 1B. An HC FLUOTAR 63 /0.90 objective lens was used.
Citations
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Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).
Elise A. Olsen,Eric C. Vonderheid,Nicola Pimpinelli,Rein Willemze,Youn H. Kim,Robert Knobler,Herschel S. Zackheim,Madeleine Duvic,Teresa Estrach,Stanford I. Lamberg,Gary S. Wood,Reinhard Dummer,Annamari Ranki,Günter Burg,Peter Heald,Mark R. Pittelkow,M.G. Bernengo,Wolfram Sterry,Liliane Laroche,Franz Trautinger,Sean Whittaker +20 more
TL;DR: These revisions are made to incorporate advances related to tumor cell biology and diagnostic techniques as pertains to mycosis fungoides and Sézary syndrome to clarify certain variables that currently impede effective interinstitution and interinvestigator communication and/or the development of standardized clinical trials in MF and SS.
Book ChapterDOI
The World Health Organization Classification of Lymphoid Neoplasms
TL;DR: The World Health Organization classification of the lymphoid neoplasms updated in 2008 represents a worldwide consensus on lymphoma diagnosis and is based in two major principles: the stratification of neoplasm according to their cell lineage and their derivation of precursor or mature cells and the definition of non-overlapping distinct diseases that are clinically relevant.
Journal ArticleDOI
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
Madeleine Duvic,Rakhshandra Talpur,Xiao Ni,Chunlei Zhang,Parul Hazarika,Cecilia Kelly,Judy Chiao,John F. Reilly,Justin L. Ricker,Victoria M. Richon,Stanley R. Frankel +10 more
TL;DR: Vorinostat demonstrated activity in heavily pretreated patients with CTCL and the 400 mg daily regimen had the most favorable safety profile and is being further evaluated.
Journal ArticleDOI
Phase IIB Multicenter Trial of Vorinostat in Patients With Persistent, Progressive, or Treatment Refractory Cutaneous T-Cell Lymphoma
Elise A. Olsen,Youn H. Kim,Timothy M. Kuzel,Theresa R. Pacheco,Francine M. Foss,Sareeta Parker,Stanley R. Frankel,Cong Chen,Justin L. Ricker,Jean Marie Arduino,Madeleine Duvic +10 more
TL;DR: Oral vorinostat was effective in treatment refractory MF/SS with an acceptable safety profile and time to response, time to progression, duration of response, and pruritus relief.
References
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Journal ArticleDOI
E.S. Jaffe, N.L. Harris, H. Stein, J.W. Vardiman (eds). World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues
Journal ArticleDOI
Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87).
TL;DR: The following diagnostic criteria are proposed to classify four clinical subtypes of HTLV‐1 associated adult T‐cell leukaemia‐lymphoma (ATL): smouldering type, 5% or more abnormal lymphocytes of T‐ cell nature in PB, normal lymphocyte level, no hypercalcaemia, and histologically‐proven lymphadenopathy and involvement of liver, spleen, skin, and lung.
Related Papers (5)
Revisions to the staging and classification of mycosis fungoides and Sezary syndrome: a proposal of the International Society for Cutaneous Lymphomas (ISCL) and the cutaneous lymphoma task force of the European Organization of Research and Treatment of Cancer (EORTC).
Elise A. Olsen,Eric C. Vonderheid,Nicola Pimpinelli,Rein Willemze,Youn H. Kim,Robert Knobler,Herschel S. Zackheim,Madeleine Duvic,Teresa Estrach,Stanford I. Lamberg,Gary S. Wood,Reinhard Dummer,Annamari Ranki,Günter Burg,Peter Heald,Mark R. Pittelkow,M.G. Bernengo,Wolfram Sterry,Liliane Laroche,Franz Trautinger,Sean Whittaker +20 more