Journal ArticleDOI
Xanthones with quinone reductase-inducing activity from the fruits of Garcinia mangostana (Mangosteen).
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TLDR
Bioactivity-guided fractionation of a dichloromethane-soluble extract of Garcinia mangostana fruits has led to the isolation and identification of five compounds, including two xanthones, 1,2-dihydro-1,8,10-trihydroxy-2-(2-hydroxypropan-2-yl)-9-(3-methylbut- 2-enyl)furo[3, 2-a].About:
This article is published in Phytochemistry.The article was published on 2008-02-01. It has received 107 citations till now. The article focuses on the topics: Garcinia mangostana & Xanthone.read more
Citations
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Journal ArticleDOI
Medicinal properties of mangosteen (Garcinia mangostana).
TL;DR: Findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far are summarized.
Journal ArticleDOI
Garcinia mangostana L.: a phytochemical and pharmacological review
TL;DR: This review highlights the development of this botanical drug into a widely used nutraceutical and its potential in terms of developing novel drug leads is assessed.
Journal ArticleDOI
Xanthones from Mangosteen Extracts as Natural Chemopreventive Agents: Potential Anticancer Drugs
TL;DR: A concise and comprehensive review of preclinical data and assess the observed anticancer effects of xanthones, supporting its remarkable potential as an anticancer agent.
Journal ArticleDOI
Lignans and Other Constituents of the Fruits of Euterpe oleracea (Açai) with Antioxidant and Cytoprotective Activities
TL;DR: Lignans have not been previously reported as constituents of this species and were found to be representative of the aryltetrahydronaphthalene, dihydrobenzofuran, furofuran, 8-O-4'-neolignan, and tetrahydrofuran structural types.
Journal ArticleDOI
In vitro antioxidant properties of mangosteen peel extract.
TL;DR: The aim of this review, after presenting analytical techniques for determining in vitro antioxidant activity of mangosteen peel extract, is to summarize available data on the factors affecting antioxidant activity.
References
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Book ChapterDOI
Role of free radicals and catalytic metal ions in human disease: an overview.
TL;DR: The chapter discusses the metabolism of transition metals, such as iron and copper, and the chelation therapy that is an approach to site-specific antioxidant protection.
Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids).
TL;DR: An approach to chemoprevention of common forms of epithelial cancer, during the period of preneoplasia, is described and the potential future usefulness of this approach to cancer prevention in man will depend on further synthetic modification of the retinoid molecule.
Journal ArticleDOI
Antioxidant Xanthones from the Pericarp of Garcinia mangostana (Mangosteen)
TL;DR: Except for compound 2, which was isolated as a minor component, the antioxidant activities of all isolates were determined using authentic and morpholinosydnonimine-derived peroxynitrite methods, and compounds 1, 8, 10, 11, and 13 were the most active.
Journal ArticleDOI
Direct measurement of NAD(P)H:quinone reductase from cells cultured in microtiter wells: a screening assay for anticarcinogenic enzyme inducers.
TL;DR: A rapid and direct assay of NAD(P)H:(quinone-acceptor) oxidoreductase (EC 1.6.99.2) activity in cultured cells suitable for identifying and purifying inducers of this detoxication enzyme is described.
Journal ArticleDOI
Chemoprotection against cancer by Phase 2 enzyme induction
TL;DR: Search for such inducer activity in broccoli led to the isolation of sulforaphane, an isothiocyanate that is a very potent Phase 2 enzyme inducer and blocks mammary tumor formation in rats.