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Journal ArticleDOI
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
TL;DR: Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression, and this information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.
Journal Article
Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children.
TL;DR: Solid variants have a high prevalence of ret/PTC3, whereas typical papillary carcinomas do not, suggesting that the different types of ret rearrangement confer neoplastic thyroid cells with distinct phenotypic properties.
Journal ArticleDOI
Poorly differentiated thyroid carcinoma: the Turin proposal for the use of uniform diagnostic criteria and an algorithmic diagnostic approach.
Marco Volante,Paola Collini,Yuri E. Nikiforov,Atsuhiko Sakamoto,Kennichi Kakudo,Ryohei Katoh,Ricardo V. Lloyd,Virginia A. LiVolsi,Mauro Papotti,Manuel Sobrinho-Simões,Gianni Bussolati,Juan Rosai +11 more
TL;DR: To compare lesions occurring in different geographic areas and the diagnostic criteria applied in those countries, a study with a panel of internationally recognized thyroid pathologists to develop consensus diagnostic criteria for PD carcinomas was designed.
Journal ArticleDOI
Pediatric thyroid cancer after the Chernobyl disaster. Pathomorphologic study of 84 cases (1991-1992) from the Republic of Belarus.
TL;DR: Starting in 1990, a definite increase in the incidence of thyroid cancer was noted in children of the Republic of Belarus, and the number of children diagnosed with thyroid cancer increased significantly.
Journal ArticleDOI
High prevalence of RET/PTC rearrangements in Ukrainian and Belarussian post-Chernobyl thyroid papillary carcinomas: a strong correlation between RET/PTC3 and the solid-follicular variant.
G. A. Thomas,H. Bunnell,H. A. Cook,E D Williams,A. Nerovnya,E. D. Cherstvoy,N D Tronko,T Bogdanova,Giovanni Chiappetta,Giuseppe Viglietto,Francesca Pentimalli,Giuliana Salvatore,Alfredo Fusco,Massimo Santoro,Giancarlo Vecchio +14 more
TL;DR: The concept that RET/PTC activation plays a central role in the pathogenesis of thyroid papillary carcinomas in both Ukraine and Belarus after the Chernobyl accident is supported.