(Z)-3α-(1,3-Dioxoisoindolin-2-yl)-17(20)-pregnene.
Yue Qi,Nan Qin,Hong-Quan Duan +2 more
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TLDR
The title compound, C29H37NO2, crystallized with two independent molecules in an asymmetric unit in which the conformation of the cyclohexyl ring of the pregnene moiety bonded to the 3α-(1,3-dioxoisoindolin-2-yl)- ring system differs: in one molecule it is in a chair conformation, while in the other it exhibits a half-chair conformation.Abstract:
The title compound, C29H37NO2, crystallized with two independent molecules in an asymmetric unit in which the conformation of the cyclohexyl ring of the pregnene moiety bonded to the 3α-(1,3-dioxoisoindolin-2-yl)- ring system differs: in one molecule it is in a chair conformation, while in the other it exhibits a half-chair conformation. The other six-membered rings in the pregnene moiety are in chair conformations and the five-membered rings are in envelope forms in both molecules. In both molecules, the 3α-(1,3-dioxoisoindolin-2-yl)- ring systems are individually approximately planar, with r.m.s. devtaions 0.0148 and 0.0264 A. The structure is consolidated by intermolecular C—H⋯O hydrogen-bonding interactions involving the carbonyl O atoms and methyl, methylene and methylidyne groups, resulting in a two-dimensional structure.read more
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(Z)-3β-(2-Chloro-anilino)-17(20)-pregnene.
TL;DR: In the pregnene fragment of the title compound, C27H38ClN, the three six- Membered rings exhibit chair conformations and the five-membered ring has a distorted envelope form with the fused C atom not bearing a methyl group as the flap atom.
References
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Ladroside (= 6′-Caffeoyl-mussaenoside), a New Iridoid Glucoside from Veronica officinalis L. (Scrophulariaceae) and the elucidation of the absolute configuration at C(8) of mussaenoside
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Pregnane alkaloids from Pachysandra axillaris
TL;DR: Nine new pregnane alkaloids, pachysamines J-R (1-9), together with seven known ones, were isolated from Pachysandra axillaris by spectroscopic methods and showed moderate activities against A-549, SK-BR-3, and PANC-1 cells.