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As a consequence, the catalytic site becomes disrupted.
Nonetheless, catalytic behavior is strongly affected by the preparation method.
The results indicate that site isolation effects occur with two of the catalytic systems used: Whereas immobilized cationic Rh-catalysts are practically not affected, the neutral Rh-catalysts lose most of their activity with increasing catalyst loading.
Catalytic results can be interpreted in terms of a modification of the acid sites distribution by the alkali metal addition, the stronger acid sites being mainly affected.
The results show that the catalytic properties are greatly affected by the supports.
Although this domain contains neither catalytic residues nor substrate sites, its removal impaired both catalytic activities, suggesting that it may be essential for active-site integrity.
The results indicated that catalytic pathway mechanisms were affected by the substrate.
The results support a model in which an allosteric site is involved, although the proximity of this putative site to the catalytic site cannot be ascertained as of yet.
We also found that the total catalytic power is affected by environmental conditions.
Geometric changes resulting from Ca2+ substitution at metal ion site A may thus be a secondary factor in the loss of catalytic activity.

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