scispace - formally typeset
Search or ask a question

Dietary isoflavones are related to stomach cancer risk? 


Best insight from top research papers

Dietary isoflavones have been studied in relation to stomach cancer risk, but the results are inconclusive. Some studies suggest that isoflavone intake may be a protective factor against gastric cancer , while others show no significant association . One meta-analysis found no significant relationship between dietary isoflavones intake and gastric cancer risk . However, another meta-analysis reported that higher dietary isoflavone intake is not associated with a decline in the risk of gastric cancer . Overall, the evidence is mixed, and more research is needed to determine the true relationship between dietary isoflavones and stomach cancer risk .

Answers from top 5 papers

More filters
Papers (5)Insight
The paper states that there is no substantial correlation between dietary isoflavones intake and the risk of gastric cancer. Further evidence from observational and trial studies is needed.
The paper does not specifically mention the relationship between dietary isoflavones and stomach cancer risk. The paper focuses on the association between soy intake and gastrointestinal (GI) cancer risk, with a stronger inverse association found for colorectal cancer (CRC).
The paper states that dietary isoflavones are significantly associated with decreased risk of stomach cancer.
The paper states that high intake of isoflavones may not be associated with the incidence of gastric cancer.
The paper states that there is no significant association between dietary isoflavones intake and gastric cancer risk.

Related Questions

How does gastric cancer affect nutrition?5 answersGastric cancer significantly impacts nutrition in patients. Studies have shown that gastric cancer patients are at high risk of malnutrition. Malnutrition negatively affects clinical outcomes, quality of life, and treatment tolerance, leading to poor physical activity and severe toxicity during chemotherapy or radiation therapy. Factors influencing nutritional status include symptom severity, difficulty in diet preparation, and employment status. Early identification of malnutrition risk is crucial to initiate appropriate nutritional support, which can reduce hospitalization length, treatment-related toxicity, and improve quality of life and treatment outcomes. Nutritional interventions, such as immunonutrition, play a vital role in preparing patients for surgery and aiding in postoperative recovery. Therefore, a comprehensive approach to nutritional support is essential in managing gastric cancer patients.
Does alcohol use increase stomach cancer risk?5 answersAlcohol use is associated with an increased risk of stomach cancer. The risk appears to be higher in men than in women. Heavy alcohol consumption, even in low quantities per session, is linked to a greater risk of gastric cancer. The risk of noncardia stomach cancer is particularly elevated in individuals who consume alcohol frequently and in higher amounts. Additionally, individuals with inactive ALDH2 genotypes, which are more common in East Asian populations, have an increased risk of gastric cancer when consuming alcohol. Moderate to heavy drinkers with inactive ALDH2 are more susceptible to gastric cancer than non-drinkers or light drinkers. Overall, these findings suggest that alcohol use, especially heavy and frequent consumption, can increase the risk of stomach cancer, particularly in certain populations and subtypes of the disease.
What is the effect of dietary folate intake on the risk of gastric cancer?4 answersDietary folate intake has been found to have a mixed effect on the risk of gastric cancer. Some studies have shown a protective effect, while others have found no significant association. A case-control study conducted by Sun-Seog Kweon et al. found no statistically significant association between dietary folate intake and gastric cancer risk overall. However, when stratified by menopausal status, higher intake of riboflavin was associated with decreased gastric cancer risk in premenopausal women, while the highest intake of folate was associated with increased gastric cancer risk in premenopausal women. Another case-control study by Jianhua Chen et al. found an inverse relationship between folate intake and gastric cancer risk, with higher folate intake associated with a decreased risk. This study also found a significant interaction between folate intake and the MTHFR C677T polymorphism, suggesting that the effect of folate intake may differ depending on genetic factors.
What is the effect of isoflavones on cardiovascular disease?4 answersIsoflavones have been studied for their effects on cardiovascular disease (CVD). Several papers suggest that isoflavones, particularly those found in soybeans, may have beneficial effects on CVD. They have been associated with a lower risk of heart failure, myocardial infarction, hypertension, and coronary artery disease. Isoflavones have also been shown to have positive effects on oxidative stress, inflammation, lipid abnormalities, and markers of bone metabolism, which are important factors in CVD. In a study of middle-aged and elderly adults, higher intake of isoflavones was associated with a significantly lower risk of subclinical CVD in women. Another study found that higher serum isoflavone levels were associated with reduced progression of carotid intima-media thickness, a marker of atherosclerosis. These findings suggest that isoflavones may have a protective effect against CVD, particularly in women. However, further research is needed to fully understand the mechanisms and potential benefits of isoflavones in managing CVD.
How does flavones impact human health?5 answersFlavones have been shown to have positive impacts on human health. They have anti-inflammatory properties that can help control chronic inflammation, which is associated with obesity and cancer. Flavones can also modulate immune responses and improve lipid profiles, leading to benefits for cardiovascular health. Additionally, flavones have been found to ameliorate symptoms of cognitive impairment and neurodegenerative diseases like Alzheimer's. They can also regulate adipocyte-macrophage crosstalk, leading to a reduction in obesity-induced inflammation. Furthermore, flavones can modulate the composition and function of the gut microbiome, resulting in positive regulation of metabolic pathways and immune responses. Overall, flavones have the potential to improve health by addressing chronic inflammation, cardiovascular health, cognitive function, and obesity-related conditions.
Determinants of health affect stomach cancer risk?4 answersDeterminants of health that affect stomach cancer risk include lifestyle factors such as red meat, pickled vegetable or alcohol consumption, low socioeconomic status, cigarette smoking, and Helicobacter pylori infection. Other risk factors include genetic predispositions, family history, and blood group A. Environmental factors like high alcohol intake, excess dietary salt, lack of refrigeration, and inadequate fruit and vegetable consumption also contribute to the risk of gastric cancer. Age, sex, and socioeconomic status are additional determinants of gastric cancer risk. Furthermore, increasing age, male sex, non-White race, and smoking are identified as risk factors for gastric cancer. It is important to consider these determinants in order to facilitate the pathogenesis of gastric malignancies and implement proper diagnostic procedures, screening programs, and prophylaxis.