Do B cells work against viruses?
Answers from top 11 papers
More filters
| Papers (11) | Insight |
|---|---|
476 Citations | We conclude that antibodies and B cells play a critical early role in the defense against disseminated infection by WNV. |
46 Citations | Thus, the polyclonal activation of B cells occurs in the absence of an antiviral humoral immune response and the immune complexes do not contain anti-LDV antibodies. |
| These data indicate that B and T cell cross-reactivity exists between influenza A and B viruses, which may have modulatory effects on the disease process and recovery. | |
195 Citations | These measurements suggest that the level of EBV-infected B cells is tightly regulated and we propose that the same homeostatic mechanisms that regulate the levels of normal B cells also regulate B cells latently infected with EBV. |
| Work with genetically modified mice suggests that the viral latent membrane protein LMP1 might allow infected B cells to access the memory compartment by an unusual route. | |
17 Citations | Studies on cell-mediated immunity against EB virus and EBV transformed B cells provide one of the most interesting and accessible systems for analyzing the host response against a transforming virus, and against its premalignant and malignant cellular products. |
| Adoptive transfer of memory cells from B+/+ mice led to virus clearance from persistently infected B+/+ recipients even after in vitro depletion of B cells, indicating that B cells or immunoglobulins are not required in the transfer population. | |
| Our results demonstrate that the majority of infectious JCV virions remain cell surface associated and do not efficiently establish infection of B cells. | |
| The results indicate an important role for B cells in host defense against C. neoformans infection and demonstrate a surprising dependence of Ab-mediated protection on B cells in this system. | |
| Interestingly, both viruses can activate infected B lymphocytes to proliferate, as does signalling by the B-cell receptor. | |
806 Citations | We propose that EBV indiscriminately infects B cells in mucosal lymphoid tissue and that these cells differentiate to become resting memory B cells that then enter the circulation. |