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David A. Thorley-Lawson
Researcher at Tufts University
Publications - 125
Citations - 17378
David A. Thorley-Lawson is an academic researcher from Tufts University. The author has contributed to research in topics: Epstein–Barr virus & Virus. The author has an hindex of 66, co-authored 125 publications receiving 16547 citations. Previous affiliations of David A. Thorley-Lawson include Tufts Medical Center & Harvard University.
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Journal ArticleDOI
Functional delivery of viral miRNAs via exosomes
D. Michiel Pegtel,Katherine Cosmopoulos,David A. Thorley-Lawson,Monique A. J. van Eijndhoven,Erik S. Hopmans,Jelle J. Lindenberg,Tanja D. de Gruijl,Thomas Wurdinger,Jaap M. Middeldorp +8 more
TL;DR: These findings are consistent with miRNA-mediated gene silencing as a potential mechanism of intercellular communication between cells of the immune system that may be exploited by the persistent human γ-herpesvirus EBV.
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A novel form of Epstein-Barr virus latency in normal B cells in vivo.
TL;DR: It is concluded that the EBV-infected cells in vivo are B cells with a nonactivated phenotype, which represents a novel form of latency in normal B cells.
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Persistence of the Epstein–Barr Virus and the Origins of Associated Lymphomas
TL;DR: This review of the life cycle of the Epstein–Barr virus explains how EBV establishes lifelong infection in a host with protective immunity against the virus.
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Epstein-Barr virus: exploiting the immune system
TL;DR: Two genes encoded by the virus — LMP1 and LMP2A — allow EBV to exploit the normal pathways of B-cell differentiation so that the EBV-infected B blast can become a resting memory cell.
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EBV Persistence in Memory B Cells In Vivo
TL;DR: It is proposed that EBV indiscriminately infects B cells in mucosal lymphoid tissue and that these cells differentiate to become resting memory B cells that then enter the circulation and persist by exploiting the mechanisms that produce and maintain long-term B cell memory.