Do mutated cells go through apoptosis?
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| Papers (10) | Insight |
|---|---|
Open access•Journal Article | It is proposed that mutated cells are eliminated through apoptosis due to accumulated DNA damage. |
17 Citations | The failure of apoptosis allows mutated cells to continue to enter the cell cycle, perpetuating the cycle of mutation and oncogenesis. |
| Moreover, we show that most cells do not undergo apoptosis after irradiation but rather cease proliferation and start a differentiation program. | |
| While enhanced cell replication may contribute to an increased frequency of mutation, apoptosis within a tissue may counteract chemical carcinogenesis through loss of mutated cells. | |
32 Citations | Abnormal cells are prone to destruction through spontaneous apoptosis or because of the immunosurveillance that needs to stay highly vigilant. |
Open access•Journal Article 88 Citations | These results support the hypothesis that apoptosis plays a crucial role in maintaining genomic integrity by selectively eliminating highly mutated cells from the population. |
| Apoptosis was classically regarded as a silent form of cell death, but mounting evidence indicates that apoptotic cells “don't go silently” and leave a heritage to the local microenvironment. | |
| Dysregulation of apoptosis can result in the persistence of mutated cells, leading to malformations, autoimmune disease, and cancer. | |
6 Citations | The inhibition of apoptosis prevents the elimination of mutation-affected cells which leads to an uncoordinated proliferation of a mutated cell clone. |
6 Citations | However, if mutation generates relative resistance to apoptosis it may result in growth advantage for the mutated cells. |
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