Docking of liver cancer causing protein with indole derivative
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The docking of liver cancer causing protein with indole derivatives has been investigated in several studies. Gao et al. designed and synthesized novel 1H-indole-2-carboxylic acid derivatives targeting the 14-3-3η protein for the treatment of liver cancer . Eldeeb et al. performed molecular docking of sulfonamide-derived isatins and indolin-2-one derivatives into the active sites of the NS5B polymerase enzyme, which is found in Hepatitis C virus (HCV) and plays a role in virus replication . Rajandran et al. and Raj et al. also conducted molecular docking studies on indole derivatives into the active sites of the NS5B polymerase enzyme for the treatment of HCV . Ibrahim et al. synthesized benzaldazine and ketazine derivatives via the condensation of carbonyl compounds with 3-(1-hydrazineylideneethyl)-1H-indole and evaluated their anticancer activities . These studies provide insights into the potential of indole derivatives for targeting liver cancer causing proteins through molecular docking.
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| Papers (5) | Insight |
|---|---|
| The paper does not mention the docking of a liver cancer causing protein with an indole derivative. The paper is about the synthesis and anticancer activities of new azines bearing indole. | |
Open access 01 Jan 2015 1 Citations | The provided paper is about docking studies of indole derivatives as Hepatitis C NS5B polymerase inhibitors. It does not mention anything about docking of liver cancer causing protein with indole derivatives. |
Open access•Journal Article | The provided paper is about molecular docking studies of indole derivatives as hepatitis C NS5B polymerase inhibitors. It does not mention docking of a liver cancer causing protein with indole derivatives. |
| The paper does not mention the docking of a liver cancer causing protein with an indole derivative. The paper is about the cytotoxic effects of newly synthesized isatin sulfonamide molecular hybrid derivatives against hepatic cancer cell lines. | |
| The paper mentions that molecular docking was conducted to analyze the anti-proliferative mechanisms of the indole derivative C11, which targets the 14-3-3η protein in liver cancer cells. |
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