Does albumin contain aromatic amino acids?
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| Albumin dialysis did not significantly affect the amino acid profile in the controls. Albumin dialysis results in a significant decrease in circulating phenolic aromatic amino acids and improvement of hepatic encephalopathy in patients with severe liver failure. | |
53 Citations | Experiments with model solutions suggest that serum albumin has a high capacity for binding aromatic amino acids (stabilized by hydrophobic interactions) at neutral pH and this is responsible for the NMR‐invisibility of Tyr and Phe in blood plasma. |
20 Citations | In other respects the albumin fractions from all three species were similar and represent balanced sources of all the essential amino acids except possibly tryptophane (not determined). |
| This suggests that albumin may have a role in the metabolism of endogenous and exogenous aromatic amides, including drugs and xenobiotics. | |
Open access•Journal Article 19 Citations | We conclude that infused amino acids promote the synthesis of albumin equally effectively in the presence or absence of a small amount of added glucose. |
31 Citations | A remarkable role of aromatic amino acids was uncovered. |
37 Citations | However, according to recent animal studies, the redox state of serum albumin is modulated by albumin turnover and may also reflect amino acid/protein nutritional status. |
105 Citations | It is concluded that amino acids play an important role in the control of albumin synthesis and that more than one mechanism is probably involved. |
| The rate of synthesis of albumin and, thus, the rate of its secretion is linked most closely to the supply of amino acids. | |
49 Citations | The results group well to the amino acid type, i. e., hydrophobic, polar, and aromatic ones. |
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