Does the application of rocker platform induced perfusion promote the degradation of hydrogels in in vitro tissue modeling?
Best insight from top research papers
The application of a rocker platform induced perfusion does not promote the degradation of hydrogels in in vitro tissue modeling .
Answers from top 5 papers
More filters
| Papers (5) | Insight |
|---|---|
| The provided paper does not mention anything about the application of a rocker platform induced perfusion and its effect on the degradation of hydrogels in in vitro tissue modeling. | |
| The provided paper does not mention the application of a rocker platform or its effect on the degradation of hydrogels in in vitro tissue modeling. | |
59 Citations | The paper does not mention the application of a rocker platform induced perfusion or its effect on the degradation of hydrogels in in vitro tissue modeling. |
4 Citations | The provided paper does not mention anything about the application of rocker platform induced perfusion or its effect on the degradation of hydrogels in in vitro tissue modeling. |
| The provided paper does not mention the application of a rocker platform or the degradation of hydrogels in in vitro tissue modeling. |
Related Questions
In which studies has a rocking plate been used in tissue modeling?5 answersA rocking plate has been used in tissue modeling studies conducted by Russell P. Tucker et al..
What are the potential advantages and limitations of using cellulose hydrogel as a scaffold for cartilage tissue engineering?5 answersCellulose hydrogel has potential advantages as a scaffold for cartilage tissue engineering. It has been shown to promote cellular adhesion and proliferation, making it suitable for combining with stem cells for cartilage repair. Cellulose hydrogels also possess advantageous compressive properties that are closer to native cartilaginous tissue, making them suitable for further studies in cartilage repair. Additionally, cellulose-based hydrogels have excellent properties such as hydrophilicity, mechanical strength, biodegradability, and biocompatibility, making them suitable for tissue engineering applications. However, there are limitations to using cellulose hydrogel as a scaffold. Enzymatic reactions can cause degradation of the hydrogel, which may affect its stability and mechanical properties. Furthermore, challenges such as achieving the desired mechanical properties and ensuring the efficacy of cartilage tissue repair need to be addressed. Despite these limitations, cellulose hydrogel shows promise as a scaffold for cartilage tissue engineering and further research is needed to overcome these challenges.
How can hydrogels be used to repair tissue?4 answersHydrogels can be used to repair tissue in several ways. Firstly, hydrogels have physicochemical properties similar to the extracellular matrix, providing a suitable microenvironment for cell proliferation, migration, and differentiation. Secondly, hydrogels have excellent shape adaptation and tissue adhesion properties, allowing them to be applied to a wide range of irregularly shaped tissue defects and adhere well for sustained and efficient repair. Thirdly, hydrogels can act as intelligent delivery systems, releasing therapeutic agents on demand and with temporal and spatial precision. Fourthly, hydrogels are self-healing and can maintain their integrity when damaged. These advantages make hydrogels suitable for repairing tissue defects in various areas such as bone, cartilage, skin, muscle, and nerve tissues. Hydrogels can mimic the composition and structural characteristics of the native extracellular matrix, providing a supportive environment for tissue regeneration. Conductive hydrogels, in particular, have unique advantages in tissue repair, including electrical signal detection, electrical stimulation for cell regulation, and promotion of cell proliferation and tissue repair-related pathways.
Hydrogel의 toughness에 따라서 keratinocyte나 fibroblast의 증식이 차이가 나?5 answersHydrogel의 toughness에 따라서 keratinocyte나 fibroblast의 증식에 차이가 있을 수 있습니다.. Hydrogel의 toughness를 조절하는 다양한 전략들이 연구되고 있으며, 이를 통해 생체적으로 안전한 재료로서의 hydrogel을 개발할 수 있습니다.. 특히, hydrogel의 toughness를 증가시키는 전략들은 생체적으로 부하를 견딜 수 있는 응용 분야에서 매우 중요합니다.. 이러한 개발된 hydrogel은 세포의 부착과 증식을 지원하며, 조직 공학 및 상처 치료 등 다양한 응용 분야에서 유용하게 사용될 수 있습니다.. 따라서, hydrogel의 toughness는 세포의 증식에 영향을 줄 수 있으며, 이는 다양한 응용 분야에서 유용하게 활용될 수 있습니다..
How mechanical simulation effect on cellular senesces?4 answersMechanical simulation has been shown to have an effect on cellular senescence. Cells have the ability to sense and respond to mechanical cues, ranging from changes in cytoskeletal arrangement to long-term epigenetic changes. Dynamic mechanical stimulations, such as those present in the extracellular matrix, can impact different cellular components and activate various mechanobiology pathways. Equiaxial stretching has been found to enhance the reprogramming efficiency of induced pluripotent stem cells (iPSCs) without affecting the viral transduction rate. Computer simulations have the potential to contribute to the understanding of cellular mechanics and improve fundamental understanding of biology. These simulations can be used to predict the effect of physical exercise on tissue health, simulate tissue responses to medical devices, and provide insights into cell mechanics in physiology and pathology.
How can we develop a screening tool to predict the long-term in vitro degradation of hydrogels?4 answersA screening tool to predict the long-term in vitro degradation of hydrogels can be developed by using a combination of experimental and computational approaches. Experimental methods such as gravimetrical, morphological, mechanical, and chemical evaluations can be used to assess the degradation behavior of hydrogels. Additionally, real-time changes in rheological properties during degradation can be measured using bulk rheology. Computational models can be employed to simulate the degradation process and predict the release profiles of molecules from degradable hydrogels. These models can take into account factors such as time-varying diffusivity, hydrogel geometry, and the evolving network topology during hydrolysis. By combining experimental data with computational modeling, it is possible to develop a screening tool that can accurately predict the long-term in vitro degradation of hydrogels.